Reproducing Infra-Slow Oscillations with Dopaminergic Modulation

Abstract In the human brain, billions of neurons construct a neural network via synaptic connections. Neuronal excitation and inhibition are transmitted to other neurons through synapses via neurotransmitters. Dopamine is one of these neurotransmitters that plays a number of important roles. There a...

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Autores principales:	Toshihiro Kobayashi, Yutaka Shimada, Kantaro Fujiwara, Tohru Ikeguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43a85c4555b04352b3c8ccab9b06bcbf
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spelling	oai:doaj.org-article:43a85c4555b04352b3c8ccab9b06bcbf2021-12-02T12:32:26ZReproducing Infra-Slow Oscillations with Dopaminergic Modulation10.1038/s41598-017-02366-z2045-2322https://doaj.org/article/43a85c4555b04352b3c8ccab9b06bcbf2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02366-zhttps://doaj.org/toc/2045-2322Abstract In the human brain, billions of neurons construct a neural network via synaptic connections. Neuronal excitation and inhibition are transmitted to other neurons through synapses via neurotransmitters. Dopamine is one of these neurotransmitters that plays a number of important roles. There are a variety of rhythms in the brain, such as alpha rhythm, beta rhythm, and so on. Infra-slow oscillation, ISO, is one of the rhythms observed in the brain, and ranges below 0.1 Hz. One of the key roles of dopamine is the generation of ISO in neural networks. Although the mechanism underlying the generation of ISO remains unknown, ISO can be generated by activation of the D1-type dopamine receptor. The D1-type receptor regulates spike timing-dependent plasticity (STDP), which is a learning rule of the change in synaptic weights. In this paper, to reproduce ISO in neural networks, we show that dopaminergic modulation of STDP is essential. More specifically, we discovered a close relationship between two dopaminergic effects: modulation of the STDP function and generation of ISO. We therefore, numerically investigated the relationship in detail and proposed a possible mechanism by which ISO is generated.Toshihiro KobayashiYutaka ShimadaKantaro FujiwaraTohru IkeguchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshihiro Kobayashi Yutaka Shimada Kantaro Fujiwara Tohru Ikeguchi Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
description	Abstract In the human brain, billions of neurons construct a neural network via synaptic connections. Neuronal excitation and inhibition are transmitted to other neurons through synapses via neurotransmitters. Dopamine is one of these neurotransmitters that plays a number of important roles. There are a variety of rhythms in the brain, such as alpha rhythm, beta rhythm, and so on. Infra-slow oscillation, ISO, is one of the rhythms observed in the brain, and ranges below 0.1 Hz. One of the key roles of dopamine is the generation of ISO in neural networks. Although the mechanism underlying the generation of ISO remains unknown, ISO can be generated by activation of the D1-type dopamine receptor. The D1-type receptor regulates spike timing-dependent plasticity (STDP), which is a learning rule of the change in synaptic weights. In this paper, to reproduce ISO in neural networks, we show that dopaminergic modulation of STDP is essential. More specifically, we discovered a close relationship between two dopaminergic effects: modulation of the STDP function and generation of ISO. We therefore, numerically investigated the relationship in detail and proposed a possible mechanism by which ISO is generated.
format	article
author	Toshihiro Kobayashi Yutaka Shimada Kantaro Fujiwara Tohru Ikeguchi
author_facet	Toshihiro Kobayashi Yutaka Shimada Kantaro Fujiwara Tohru Ikeguchi
author_sort	Toshihiro Kobayashi
title	Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
title_short	Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
title_full	Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
title_fullStr	Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
title_full_unstemmed	Reproducing Infra-Slow Oscillations with Dopaminergic Modulation
title_sort	reproducing infra-slow oscillations with dopaminergic modulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43a85c4555b04352b3c8ccab9b06bcbf
work_keys_str_mv	AT toshihirokobayashi reproducinginfraslowoscillationswithdopaminergicmodulation AT yutakashimada reproducinginfraslowoscillationswithdopaminergicmodulation AT kantarofujiwara reproducinginfraslowoscillationswithdopaminergicmodulation AT tohruikeguchi reproducinginfraslowoscillationswithdopaminergicmodulation
_version_	1718394090920345600

Reproducing Infra-Slow Oscillations with Dopaminergic Modulation

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