Modulating drug resistance by targeting BCRP/ABCG2 using retrovirus-mediated RNA interference.
<h4>Background</h4>The BCRP/ABCG2 transporter, which mediates drug resistance in many types of cells, depends on energy provided by ATP hydrolysis. Here, a retrovirus encoding a shRNA targeting the ATP-binding domain of this protein was used to screen for highly efficient agents that cou...
Guardado en:
Autores principales: | Ni Xie, Lisha Mou, Jianhui Yuan, Wenlan Liu, Tingting Deng, Zigang Li, Yi Jing, Zhangli Hu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/43a98db68abb48c88b579509a6b92559 |
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