Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

Mitochondrial diseases, including those caused by defects in complex III of the respiratory chain, lack curative treatments. Here the authors report that the small molecule pyocyanin has beneficial effects in cells derived from patients with complex III-deficiency as well as in fly and zebrafish gen...

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Autores principales:	Roberta Peruzzo, Samantha Corrà, Roberto Costa, Michele Brischigliaro, Tatiana Varanita, Lucia Biasutto, Chiara Rampazzo, Daniele Ghezzi, Luigi Leanza, Mario Zoratti, Massimo Zeviani, Cristiano De Pittà, Carlo Viscomi, Rodolfo Costa, Ildikò Szabò
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43a9b3426f6b484aad43fa64d8021ac2
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spelling	oai:doaj.org-article:43a9b3426f6b484aad43fa64d8021ac22021-12-02T18:15:27ZExploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction10.1038/s41467-021-22062-x2041-1723https://doaj.org/article/43a9b3426f6b484aad43fa64d8021ac22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22062-xhttps://doaj.org/toc/2041-1723Mitochondrial diseases, including those caused by defects in complex III of the respiratory chain, lack curative treatments. Here the authors report that the small molecule pyocyanin has beneficial effects in cells derived from patients with complex III-deficiency as well as in fly and zebrafish genetic models with reduced complex III activity.Roberta PeruzzoSamantha CorràRoberto CostaMichele BrischigliaroTatiana VaranitaLucia BiasuttoChiara RampazzoDaniele GhezziLuigi LeanzaMario ZorattiMassimo ZevianiCristiano De PittàCarlo ViscomiRodolfo CostaIldikò SzabòNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roberta Peruzzo Samantha Corrà Roberto Costa Michele Brischigliaro Tatiana Varanita Lucia Biasutto Chiara Rampazzo Daniele Ghezzi Luigi Leanza Mario Zoratti Massimo Zeviani Cristiano De Pittà Carlo Viscomi Rodolfo Costa Ildikò Szabò Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
description	Mitochondrial diseases, including those caused by defects in complex III of the respiratory chain, lack curative treatments. Here the authors report that the small molecule pyocyanin has beneficial effects in cells derived from patients with complex III-deficiency as well as in fly and zebrafish genetic models with reduced complex III activity.
format	article
author	Roberta Peruzzo Samantha Corrà Roberto Costa Michele Brischigliaro Tatiana Varanita Lucia Biasutto Chiara Rampazzo Daniele Ghezzi Luigi Leanza Mario Zoratti Massimo Zeviani Cristiano De Pittà Carlo Viscomi Rodolfo Costa Ildikò Szabò
author_facet	Roberta Peruzzo Samantha Corrà Roberto Costa Michele Brischigliaro Tatiana Varanita Lucia Biasutto Chiara Rampazzo Daniele Ghezzi Luigi Leanza Mario Zoratti Massimo Zeviani Cristiano De Pittà Carlo Viscomi Rodolfo Costa Ildikò Szabò
author_sort	Roberta Peruzzo
title	Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
title_short	Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
title_full	Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
title_fullStr	Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
title_full_unstemmed	Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
title_sort	exploiting pyocyanin to treat mitochondrial disease due to respiratory complex iii dysfunction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43a9b3426f6b484aad43fa64d8021ac2
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Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

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