Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.

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Autores principales:	Matthieu D. Lavigne, Dimitris Konstantopoulos, Katerina Z. Ntakou-Zamplara, Anastasios Liakos, Maria Fousteri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43adcd781e174d94a8fcc1b10dd0a0dd
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spelling	oai:doaj.org-article:43adcd781e174d94a8fcc1b10dd0a0dd2021-12-02T14:41:59ZGlobal unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate10.1038/s41467-017-02145-42041-1723https://doaj.org/article/43adcd781e174d94a8fcc1b10dd0a0dd2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02145-4https://doaj.org/toc/2041-1723Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.Matthieu D. LavigneDimitris KonstantopoulosKaterina Z. Ntakou-ZamplaraAnastasios LiakosMaria FousteriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthieu D. Lavigne Dimitris Konstantopoulos Katerina Z. Ntakou-Zamplara Anastasios Liakos Maria Fousteri Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
description	Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.
format	article
author	Matthieu D. Lavigne Dimitris Konstantopoulos Katerina Z. Ntakou-Zamplara Anastasios Liakos Maria Fousteri
author_facet	Matthieu D. Lavigne Dimitris Konstantopoulos Katerina Z. Ntakou-Zamplara Anastasios Liakos Maria Fousteri
author_sort	Matthieu D. Lavigne
title	Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_short	Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_full	Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_fullStr	Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_full_unstemmed	Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_sort	global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43adcd781e174d94a8fcc1b10dd0a0dd
work_keys_str_mv	AT matthieudlavigne globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate AT dimitriskonstantopoulos globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate AT katerinazntakouzamplara globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate AT anastasiosliakos globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate AT mariafousteri globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate
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Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

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