Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

Abstract Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiologi...

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Autores principales:	Isabel Belinchón-Romero, Pablo Bellot, David Romero-Pérez, Isolina Herraiz-Romero, Francisco Marco, Rubén Frances, José-Manuel Ramos-Rincón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43b00955131a4d21a5233231342304b4
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spelling	oai:doaj.org-article:43b00955131a4d21a5233231342304b42021-12-02T18:27:47ZNon-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients10.1038/s41598-021-88043-82045-2322https://doaj.org/article/43b00955131a4d21a5233231342304b42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88043-8https://doaj.org/toc/2045-2322Abstract Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index ≥ 30 kg/m2, homeostatic model assessment of insulin resistance ≥ 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-α (p = 0.002) and TGF-β (p = 0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p = 0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.Isabel Belinchón-RomeroPablo BellotDavid Romero-PérezIsolina Herraiz-RomeroFrancisco MarcoRubén FrancesJosé-Manuel Ramos-RincónNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabel Belinchón-Romero Pablo Bellot David Romero-Pérez Isolina Herraiz-Romero Francisco Marco Rubén Frances José-Manuel Ramos-Rincón Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
description	Abstract Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index ≥ 30 kg/m2, homeostatic model assessment of insulin resistance ≥ 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-α (p = 0.002) and TGF-β (p = 0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p = 0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.
format	article
author	Isabel Belinchón-Romero Pablo Bellot David Romero-Pérez Isolina Herraiz-Romero Francisco Marco Rubén Frances José-Manuel Ramos-Rincón
author_facet	Isabel Belinchón-Romero Pablo Bellot David Romero-Pérez Isolina Herraiz-Romero Francisco Marco Rubén Frances José-Manuel Ramos-Rincón
author_sort	Isabel Belinchón-Romero
title	Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
title_short	Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
title_full	Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
title_fullStr	Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
title_full_unstemmed	Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
title_sort	non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43b00955131a4d21a5233231342304b4
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Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

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