De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations

The majority of the human reference genome assembly is represented as a single consensus haplotype. Here, Wong et al. analyze de novo assemblies of 17 diverse, haplotype-resolved genomes to gain insights into the structure of genetic diversity and compile a list of alternative haplotypes across popu...

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Autores principales:	Karen H. Y. Wong, Michal Levy-Sakin, Pui-Yan Kwok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43b13b0e4f3246f98fc4568886f9a55e
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spelling	oai:doaj.org-article:43b13b0e4f3246f98fc4568886f9a55e2021-12-02T14:39:25ZDe novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations10.1038/s41467-018-05513-w2041-1723https://doaj.org/article/43b13b0e4f3246f98fc4568886f9a55e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05513-whttps://doaj.org/toc/2041-1723The majority of the human reference genome assembly is represented as a single consensus haplotype. Here, Wong et al. analyze de novo assemblies of 17 diverse, haplotype-resolved genomes to gain insights into the structure of genetic diversity and compile a list of alternative haplotypes across populations.Karen H. Y. WongMichal Levy-SakinPui-Yan KwokNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen H. Y. Wong Michal Levy-Sakin Pui-Yan Kwok De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
description	The majority of the human reference genome assembly is represented as a single consensus haplotype. Here, Wong et al. analyze de novo assemblies of 17 diverse, haplotype-resolved genomes to gain insights into the structure of genetic diversity and compile a list of alternative haplotypes across populations.
format	article
author	Karen H. Y. Wong Michal Levy-Sakin Pui-Yan Kwok
author_facet	Karen H. Y. Wong Michal Levy-Sakin Pui-Yan Kwok
author_sort	Karen H. Y. Wong
title	De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
title_short	De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
title_full	De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
title_fullStr	De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
title_full_unstemmed	De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
title_sort	de novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/43b13b0e4f3246f98fc4568886f9a55e
work_keys_str_mv	AT karenhywong denovohumangenomeassembliesrevealspectrumofalternativehaplotypesindiversepopulations AT michallevysakin denovohumangenomeassembliesrevealspectrumofalternativehaplotypesindiversepopulations AT puiyankwok denovohumangenomeassembliesrevealspectrumofalternativehaplotypesindiversepopulations
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De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations

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