The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.

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Autores principales:	Giovanni S. Offeddu, Cynthia Hajal, Colleen R. Foley, Zhengpeng Wan, Lina Ibrahim, Mark F. Coughlin, Roger D. Kamm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/43b59cb8b39a432e9084aba3c7f1be2c
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spelling	oai:doaj.org-article:43b59cb8b39a432e9084aba3c7f1be2c2021-12-02T13:33:44ZThe cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination10.1038/s42003-021-01774-22399-3642https://doaj.org/article/43b59cb8b39a432e9084aba3c7f1be2c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01774-2https://doaj.org/toc/2399-3642Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.Giovanni S. OffedduCynthia HajalColleen R. FoleyZhengpeng WanLina IbrahimMark F. CoughlinRoger D. KammNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
description	Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.
format	article
author	Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm
author_facet	Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm
author_sort	Giovanni S. Offeddu
title	The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
title_short	The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
title_full	The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
title_fullStr	The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
title_full_unstemmed	The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
title_sort	cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43b59cb8b39a432e9084aba3c7f1be2c
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The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

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