An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies

Specific transcriptional changes in microglia associated with Alzheimer’s disease have been reported. Here, the authors show that transcriptional analysis of human hydrocephalus biopsies identifies changes in immune response genes associated with early AD pathology, including cognitive decline.

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Autores principales:	Wenrui Huang, Anne Marie Bartosch, Harrison Xiao, Suvrajit Maji, Elliot H. H. Youth, Xena Flowers, Sandra Leskinen, Zeljko Tomljanovic, Gail Iodice, Deborah Boyett, Eleonora Spinazzi, Vilas Menon, Robert A. McGovern, Guy M. McKhann, Andrew F. Teich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43b5c7a214414bc4bb15263806a47f08
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spelling	oai:doaj.org-article:43b5c7a214414bc4bb15263806a47f082021-12-02T18:51:29ZAn immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies10.1038/s41467-021-25902-y2041-1723https://doaj.org/article/43b5c7a214414bc4bb15263806a47f082021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25902-yhttps://doaj.org/toc/2041-1723Specific transcriptional changes in microglia associated with Alzheimer’s disease have been reported. Here, the authors show that transcriptional analysis of human hydrocephalus biopsies identifies changes in immune response genes associated with early AD pathology, including cognitive decline.Wenrui HuangAnne Marie BartoschHarrison XiaoSuvrajit MajiElliot H. H. YouthXena FlowersSandra LeskinenZeljko TomljanovicGail IodiceDeborah BoyettEleonora SpinazziVilas MenonRobert A. McGovernGuy M. McKhannAndrew F. TeichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenrui Huang Anne Marie Bartosch Harrison Xiao Suvrajit Maji Elliot H. H. Youth Xena Flowers Sandra Leskinen Zeljko Tomljanovic Gail Iodice Deborah Boyett Eleonora Spinazzi Vilas Menon Robert A. McGovern Guy M. McKhann Andrew F. Teich An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
description	Specific transcriptional changes in microglia associated with Alzheimer’s disease have been reported. Here, the authors show that transcriptional analysis of human hydrocephalus biopsies identifies changes in immune response genes associated with early AD pathology, including cognitive decline.
format	article
author	Wenrui Huang Anne Marie Bartosch Harrison Xiao Suvrajit Maji Elliot H. H. Youth Xena Flowers Sandra Leskinen Zeljko Tomljanovic Gail Iodice Deborah Boyett Eleonora Spinazzi Vilas Menon Robert A. McGovern Guy M. McKhann Andrew F. Teich
author_facet	Wenrui Huang Anne Marie Bartosch Harrison Xiao Suvrajit Maji Elliot H. H. Youth Xena Flowers Sandra Leskinen Zeljko Tomljanovic Gail Iodice Deborah Boyett Eleonora Spinazzi Vilas Menon Robert A. McGovern Guy M. McKhann Andrew F. Teich
author_sort	Wenrui Huang
title	An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
title_short	An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
title_full	An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
title_fullStr	An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
title_full_unstemmed	An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
title_sort	immune response characterizes early alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43b5c7a214414bc4bb15263806a47f08
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An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies

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