Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

Besides the well-known double-helical conformation, DNA is capable of folding into various noncanonical arrangements, such as G-quadruplexes (G4s) and i-motifs (iMs), whose occurrence in gene promoters, replication origins, and telomeres highlights the breadth of biological processes that they might...

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Main Authors: Anna Di Porzio, Ubaldina Galli, Jussara Amato, Pasquale Zizza, Sara Iachettini, Nunzia Iaccarino, Simona Marzano, Federica Santoro, Diego Brancaccio, Alfonso Carotenuto, Stefano De Tito, Annamaria Biroccio, Bruno Pagano, Gian Cesare Tron, Antonio Randazzo
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
G-quadruplex
i-motif
bis-triazolyl-pyridine derivatives
click chemistry
biophysical study
immunofluorescence microscopy
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/43b712317829433d906c54d21dabe9e5
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https://doaj.org/article/43b712317829433d906c54d21dabe9e5

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