Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.

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Autores principales:	Chen Zhao, Haripriya Sridharan, Ran Chen, Darren P. Baker, Shanshan Wang, Robert M. Krug
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c
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spelling	oai:doaj.org-article:43b757d7acbd47d3bdbf6796ccfb079c2021-12-02T17:32:19ZInfluenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins10.1038/ncomms127542041-1723https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12754https://doaj.org/toc/2041-1723The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.Chen ZhaoHaripriya SridharanRan ChenDarren P. BakerShanshan WangRobert M. KrugNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Zhao Haripriya Sridharan Ran Chen Darren P. Baker Shanshan Wang Robert M. Krug Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
description	The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.
format	article
author	Chen Zhao Haripriya Sridharan Ran Chen Darren P. Baker Shanshan Wang Robert M. Krug
author_facet	Chen Zhao Haripriya Sridharan Ran Chen Darren P. Baker Shanshan Wang Robert M. Krug
author_sort	Chen Zhao
title	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
title_short	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
title_full	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
title_fullStr	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
title_full_unstemmed	Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
title_sort	influenza b virus non-structural protein 1 counteracts isg15 antiviral activity by sequestering isgylated viral proteins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c
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Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

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