Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.
Saved in:
Main Authors: | Chen Zhao, Haripriya Sridharan, Ran Chen, Darren P. Baker, Shanshan Wang, Robert M. Krug |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
|
Subjects: | |
Online Access: | https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
by: Sonia Alcalá, et al.
Published: (2020) -
ISG15 deficiency and increased viral resistance in humans but not mice
by: Scott D. Speer, et al.
Published: (2016) -
The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.
by: Caroline E Lilley, et al.
Published: (2011) -
ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review
by: Mengdi Zhang, et al.
Published: (2021) -
The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins
by: Christopher M. Weiss, et al.
Published: (2018)