Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Cas9 can be used to rapidly generate sarcoma models.

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Autores principales:	Jianguo Huang, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, David Van Mater, William C. Eward, Diana M. Cardona, Lixia Luo, Yan Ma, Omar M. Lopez, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Anupama Reddy, Sandeep S. Dave, Charles A. Gersbach, Rebecca D. Dodd, David G. Kirsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b419
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spelling	oai:doaj.org-article:43b8c0058e5a4216b4fb7dadf1a3b4192021-12-02T17:06:30ZGeneration and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma10.1038/ncomms159992041-1723https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b4192017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15999https://doaj.org/toc/2041-1723Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Cas9 can be used to rapidly generate sarcoma models.Jianguo HuangMark ChenMelodi Javid WhitleyHsuan-Cheng KuoEric S. XuAndrea WalensYvonne M. MoweryDavid Van MaterWilliam C. EwardDiana M. CardonaLixia LuoYan MaOmar M. LopezChristopher E. NelsonJacqueline N. Robinson-HammAnupama ReddySandeep S. DaveCharles A. GersbachRebecca D. DoddDavid G. KirschNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianguo Huang Mark Chen Melodi Javid Whitley Hsuan-Cheng Kuo Eric S. Xu Andrea Walens Yvonne M. Mowery David Van Mater William C. Eward Diana M. Cardona Lixia Luo Yan Ma Omar M. Lopez Christopher E. Nelson Jacqueline N. Robinson-Hamm Anupama Reddy Sandeep S. Dave Charles A. Gersbach Rebecca D. Dodd David G. Kirsch Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
description	Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Cas9 can be used to rapidly generate sarcoma models.
format	article
author	Jianguo Huang Mark Chen Melodi Javid Whitley Hsuan-Cheng Kuo Eric S. Xu Andrea Walens Yvonne M. Mowery David Van Mater William C. Eward Diana M. Cardona Lixia Luo Yan Ma Omar M. Lopez Christopher E. Nelson Jacqueline N. Robinson-Hamm Anupama Reddy Sandeep S. Dave Charles A. Gersbach Rebecca D. Dodd David G. Kirsch
author_facet	Jianguo Huang Mark Chen Melodi Javid Whitley Hsuan-Cheng Kuo Eric S. Xu Andrea Walens Yvonne M. Mowery David Van Mater William C. Eward Diana M. Cardona Lixia Luo Yan Ma Omar M. Lopez Christopher E. Nelson Jacqueline N. Robinson-Hamm Anupama Reddy Sandeep S. Dave Charles A. Gersbach Rebecca D. Dodd David G. Kirsch
author_sort	Jianguo Huang
title	Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
title_short	Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
title_full	Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
title_fullStr	Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
title_full_unstemmed	Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
title_sort	generation and comparison of crispr-cas9 and cre-mediated genetically engineered mouse models of sarcoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b419
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Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

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