Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population

Objectives: The growing prevalence of obesity rates worldwide is associated with an upsurge in its comorbidities, particularly type 2 diabetes mellitus (T2DM). Bariatric surgery is a proven treatment modality for producing sustained weight loss and resolution of associated T2DM providing marked impr...

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Autores principales:	Manish Khaitan, Riddhish Gadani, Koshish Nandan Pokharel
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	excess weight loss laparoscopic sleeve gastrectomy mini-gastric bypass roux-en-y gastric bypass type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/43bae4659da34aea9690f846f067d726
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spelling	oai:doaj.org-article:43bae4659da34aea9690f846f067d7262021-11-25T07:47:21ZEvaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population2673-17972673-173810.1159/000518856https://doaj.org/article/43bae4659da34aea9690f846f067d7262021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/518856https://doaj.org/toc/2673-1797https://doaj.org/toc/2673-1738Objectives: The growing prevalence of obesity rates worldwide is associated with an upsurge in its comorbidities, particularly type 2 diabetes mellitus (T2DM). Bariatric surgery is a proven treatment modality for producing sustained weight loss and resolution of associated T2DM providing marked improvement in quality of life with rapid recovery. This study aims to investigate the effects of laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB), and mini-gastric bypass (MGB) on obese patients suffering from T2DM in the Indian population and their long-term association with regard to diabetes remission, resolution of comorbidities, and percentage EWL. Methods: Retrospective data of obese patients with T2DM (preoperative BMI 45.37 ± 8.1) who underwent bariatric surgery (RYGB, LSG, and MGB) were analyzed in this study over a period of 9 years. The mean follow-up period was 2.2 years. Following surgery, the clinical outcome on BMI, resolution of percentage weight loss, and T2DM were studied. The predictive factors of diabetic remission after surgery were determined. Student’s t test and ANOVA and McNemar’s test were applied. Results: Out of a total of 274 patients, complete remission of T2DM was achieved in 52.9% (n = 145) with mean fasting blood glucose and glycated hemoglobin values being 6.1 ± 0.769 (p = 0.00) at 1 year after surgery. The independent predictive factors of remission were age, gender, BMI, preoperative comorbidities, and % EWL. Gender had no correlation with the chance of achieving disease remission. Conclusion: Based on our results, bariatric surgery proves to be a successful treatment option resulting in sustained weight loss in obese patients suffering from T2DM. It is found to be beneficial for the long-term resolution of T2DM and improving comorbidities such as hypertension and dyslipidemia. The outcome of the different surgical methods is found to be similar for all patients irrespective of the independent predictors of complete remission.Manish KhaitanRiddhish GadaniKoshish Nandan PokharelKarger Publishersarticleexcess weight losslaparoscopic sleeve gastrectomymini-gastric bypassroux-en-y gastric bypasstype 2 diabetes mellitusDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDubai Diabetes and Endocrinology Journal, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	excess weight loss laparoscopic sleeve gastrectomy mini-gastric bypass roux-en-y gastric bypass type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	excess weight loss laparoscopic sleeve gastrectomy mini-gastric bypass roux-en-y gastric bypass type 2 diabetes mellitus Diseases of the endocrine glands. Clinical endocrinology RC648-665 Manish Khaitan Riddhish Gadani Koshish Nandan Pokharel Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
description	Objectives: The growing prevalence of obesity rates worldwide is associated with an upsurge in its comorbidities, particularly type 2 diabetes mellitus (T2DM). Bariatric surgery is a proven treatment modality for producing sustained weight loss and resolution of associated T2DM providing marked improvement in quality of life with rapid recovery. This study aims to investigate the effects of laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB), and mini-gastric bypass (MGB) on obese patients suffering from T2DM in the Indian population and their long-term association with regard to diabetes remission, resolution of comorbidities, and percentage EWL. Methods: Retrospective data of obese patients with T2DM (preoperative BMI 45.37 ± 8.1) who underwent bariatric surgery (RYGB, LSG, and MGB) were analyzed in this study over a period of 9 years. The mean follow-up period was 2.2 years. Following surgery, the clinical outcome on BMI, resolution of percentage weight loss, and T2DM were studied. The predictive factors of diabetic remission after surgery were determined. Student’s t test and ANOVA and McNemar’s test were applied. Results: Out of a total of 274 patients, complete remission of T2DM was achieved in 52.9% (n = 145) with mean fasting blood glucose and glycated hemoglobin values being 6.1 ± 0.769 (p = 0.00) at 1 year after surgery. The independent predictive factors of remission were age, gender, BMI, preoperative comorbidities, and % EWL. Gender had no correlation with the chance of achieving disease remission. Conclusion: Based on our results, bariatric surgery proves to be a successful treatment option resulting in sustained weight loss in obese patients suffering from T2DM. It is found to be beneficial for the long-term resolution of T2DM and improving comorbidities such as hypertension and dyslipidemia. The outcome of the different surgical methods is found to be similar for all patients irrespective of the independent predictors of complete remission.
format	article
author	Manish Khaitan Riddhish Gadani Koshish Nandan Pokharel
author_facet	Manish Khaitan Riddhish Gadani Koshish Nandan Pokharel
author_sort	Manish Khaitan
title	Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
title_short	Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
title_full	Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
title_fullStr	Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
title_full_unstemmed	Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population
title_sort	evaluation of the effects of bariatric surgery in terms of weight loss and diabetes remission in the indian population
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/43bae4659da34aea9690f846f067d726
work_keys_str_mv	AT manishkhaitan evaluationoftheeffectsofbariatricsurgeryintermsofweightlossanddiabetesremissionintheindianpopulation AT riddhishgadani evaluationoftheeffectsofbariatricsurgeryintermsofweightlossanddiabetesremissionintheindianpopulation AT koshishnandanpokharel evaluationoftheeffectsofbariatricsurgeryintermsofweightlossanddiabetesremissionintheindianpopulation
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Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population

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