Antineoplastics Encapsulated in Nanostructured Lipid Carriers

Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and l...

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Autores principales:	Gustavo Henrique Rodrigues da Silva, Ludmilla David de Moura, Fabíola Vieira de Carvalho, Gabriela Geronimo, Talita Cesarim Mendonça, Fernando Freitas de Lima, Eneida de Paula
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antineoplastics drug delivery nanostructured lipid carriers cancer Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/43bf0933d3f9401a9fe846784f1432e2
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spelling	oai:doaj.org-article:43bf0933d3f9401a9fe846784f1432e22021-11-25T18:28:31ZAntineoplastics Encapsulated in Nanostructured Lipid Carriers10.3390/molecules262269291420-3049https://doaj.org/article/43bf0933d3f9401a9fe846784f1432e22021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6929https://doaj.org/toc/1420-3049Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactants. NLC have high upload capacity for lipophilic drugs, such as the majority of AAs. These nanoparticles can be prepared with a diversity of biocompatible (synthetic or natural) lipid blends, administered by different routes and functionalised for targeting purposes. This review focused on the research carried out from 2000 to now, regarding NLC formulations for AAs (antimetabolites, antimitotics, alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for codelivery of AAs were also considered, as well as those for non-classical drugs and therapies (natural products and photosensitisers). NLC have emerged as powerful DDS to improve the bioavailability, targeting and efficacy of antineoplastics, while decreasing their toxic effect in the treatment of different types of cancer.Gustavo Henrique Rodrigues da SilvaLudmilla David de MouraFabíola Vieira de CarvalhoGabriela GeronimoTalita Cesarim MendonçaFernando Freitas de LimaEneida de PaulaMDPI AGarticleantineoplasticsdrug deliverynanostructured lipid carrierscancerOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6929, p 6929 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antineoplastics drug delivery nanostructured lipid carriers cancer Organic chemistry QD241-441
spellingShingle	antineoplastics drug delivery nanostructured lipid carriers cancer Organic chemistry QD241-441 Gustavo Henrique Rodrigues da Silva Ludmilla David de Moura Fabíola Vieira de Carvalho Gabriela Geronimo Talita Cesarim Mendonça Fernando Freitas de Lima Eneida de Paula Antineoplastics Encapsulated in Nanostructured Lipid Carriers
description	Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactants. NLC have high upload capacity for lipophilic drugs, such as the majority of AAs. These nanoparticles can be prepared with a diversity of biocompatible (synthetic or natural) lipid blends, administered by different routes and functionalised for targeting purposes. This review focused on the research carried out from 2000 to now, regarding NLC formulations for AAs (antimetabolites, antimitotics, alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for codelivery of AAs were also considered, as well as those for non-classical drugs and therapies (natural products and photosensitisers). NLC have emerged as powerful DDS to improve the bioavailability, targeting and efficacy of antineoplastics, while decreasing their toxic effect in the treatment of different types of cancer.
format	article
author	Gustavo Henrique Rodrigues da Silva Ludmilla David de Moura Fabíola Vieira de Carvalho Gabriela Geronimo Talita Cesarim Mendonça Fernando Freitas de Lima Eneida de Paula
author_facet	Gustavo Henrique Rodrigues da Silva Ludmilla David de Moura Fabíola Vieira de Carvalho Gabriela Geronimo Talita Cesarim Mendonça Fernando Freitas de Lima Eneida de Paula
author_sort	Gustavo Henrique Rodrigues da Silva
title	Antineoplastics Encapsulated in Nanostructured Lipid Carriers
title_short	Antineoplastics Encapsulated in Nanostructured Lipid Carriers
title_full	Antineoplastics Encapsulated in Nanostructured Lipid Carriers
title_fullStr	Antineoplastics Encapsulated in Nanostructured Lipid Carriers
title_full_unstemmed	Antineoplastics Encapsulated in Nanostructured Lipid Carriers
title_sort	antineoplastics encapsulated in nanostructured lipid carriers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/43bf0933d3f9401a9fe846784f1432e2
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Antineoplastics Encapsulated in Nanostructured Lipid Carriers

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