Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating

Fuxia Dong,1,2 Yunchang Xie,1 Jianping Qi,1 Fuqiang Hu,3 Yi Lu,1 Sanming Li,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, Shanghai, People’s Republic of China; 2School of Pharmacy, Shenyang Pharmaceutical University...

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Autores principales:	Dong F, Xie Y, Qi J, Hu F, Lu Y, Li S, Wu W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/43c056baedee4d56ad95a0e731c24e66
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spelling	oai:doaj.org-article:43c056baedee4d56ad95a0e731c24e662021-12-02T01:50:40ZBile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating1176-91141178-2013https://doaj.org/article/43c056baedee4d56ad95a0e731c24e662013-04-01T00:00:00Zhttp://www.dovepress.com/bile-saltphospholipid-mixed-micelle-precursor-pellets-prepared-by-flui-a12885https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Fuxia Dong,1,2 Yunchang Xie,1 Jianping Qi,1 Fuqiang Hu,3 Yi Lu,1 Sanming Li,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, Shanghai, People’s Republic of China; 2School of Pharmacy, Shenyang Pharmaceutical University, Liaoning, People’s Republic of China; 3School of Pharmacy, Zhejiang University, Hangzhou, People’s Republic of China Abstract: Bile salt/phospholipid mixed micelles (MMs) are potent carriers used for oral absorption of drugs that are poorly soluble in water; however, there are many limitations associated with liquid formulations. In the current study, the feasibility of preparing bile salt/phospholipid MM precursor (preMM) pellets with high oral bioavailability, using fluid-bed coating technology, was examined. In this study, fenofibrate (FB) and sodium deoxycholate (SDC) were used as the model drug and the bile salt, respectively. To prepare the MMs and to serve as the micellular carrier, a weight ratio of 4:6 was selected for the sodium deoxycholate/phospholipids based on the ternary phase diagram. Polyethylene glycol (PEG) 6000 was selected as the dispersion matrix for precipitation of the MMs onto pellets, since it can enhance the solubilizing ability of the MMs. Coating of the MMs onto the pellets using the fluid-bed coating technology was efficient and the pellets were spherical and intact. MMs could be easily reconstituted from preMM pellets in water. Although they existed in a crystalline state in the preMM pellets, FB could be encapsulated into the reconstituted MMs, and the MMs were redispersed better than solid dispersion pellets (FB:PEG = 1:3) and Lipanthyl®. The redispersibility of the preMM pellets increased with the increase of the FB/PEG/micellar carrier. PreMM pellets with a FB:PEG:micellar carrier ratio of 1:1.5:1.5 showed 284% and 145% bioavailability relative to Lipanthyl® and solid dispersion pellets (FB:PEG = 1:3), respectively. Fluid-bed coating technology has considerable potential for use in preparing sodium deoxycholate/phospholipid preMM pellets, with enhanced oral bioavailability for poorly water-soluble drugs. Keywords: mixed micelles, bile salts, phospholipids, fluid-bed coating, oral bioavailabilityDong FXie YQi JHu FLu YLi SWu WDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1653-1663 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dong F Xie Y Qi J Hu F Lu Y Li S Wu W Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
description	Fuxia Dong,1,2 Yunchang Xie,1 Jianping Qi,1 Fuqiang Hu,3 Yi Lu,1 Sanming Li,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, Shanghai, People’s Republic of China; 2School of Pharmacy, Shenyang Pharmaceutical University, Liaoning, People’s Republic of China; 3School of Pharmacy, Zhejiang University, Hangzhou, People’s Republic of China Abstract: Bile salt/phospholipid mixed micelles (MMs) are potent carriers used for oral absorption of drugs that are poorly soluble in water; however, there are many limitations associated with liquid formulations. In the current study, the feasibility of preparing bile salt/phospholipid MM precursor (preMM) pellets with high oral bioavailability, using fluid-bed coating technology, was examined. In this study, fenofibrate (FB) and sodium deoxycholate (SDC) were used as the model drug and the bile salt, respectively. To prepare the MMs and to serve as the micellular carrier, a weight ratio of 4:6 was selected for the sodium deoxycholate/phospholipids based on the ternary phase diagram. Polyethylene glycol (PEG) 6000 was selected as the dispersion matrix for precipitation of the MMs onto pellets, since it can enhance the solubilizing ability of the MMs. Coating of the MMs onto the pellets using the fluid-bed coating technology was efficient and the pellets were spherical and intact. MMs could be easily reconstituted from preMM pellets in water. Although they existed in a crystalline state in the preMM pellets, FB could be encapsulated into the reconstituted MMs, and the MMs were redispersed better than solid dispersion pellets (FB:PEG = 1:3) and Lipanthyl®. The redispersibility of the preMM pellets increased with the increase of the FB/PEG/micellar carrier. PreMM pellets with a FB:PEG:micellar carrier ratio of 1:1.5:1.5 showed 284% and 145% bioavailability relative to Lipanthyl® and solid dispersion pellets (FB:PEG = 1:3), respectively. Fluid-bed coating technology has considerable potential for use in preparing sodium deoxycholate/phospholipid preMM pellets, with enhanced oral bioavailability for poorly water-soluble drugs. Keywords: mixed micelles, bile salts, phospholipids, fluid-bed coating, oral bioavailability
format	article
author	Dong F Xie Y Qi J Hu F Lu Y Li S Wu W
author_facet	Dong F Xie Y Qi J Hu F Lu Y Li S Wu W
author_sort	Dong F
title	Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
title_short	Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
title_full	Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
title_fullStr	Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
title_full_unstemmed	Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
title_sort	bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/43c056baedee4d56ad95a0e731c24e66
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Bile salt/phospholipid mixed micelle precursor pellets prepared by fluid-bed coating

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