Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment

Abstract Background Matrix metalloproteinases (MMPs) catalyzes the degradation of the extracellular matrix components and have a major role in many physiological processes including wound healing. In the current study, we examined the correlation of baseline MMPs 1, 2, 7, and 9 expressions with peri...

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Autores principales:	Muhammad Adeel Ahmed, Muhammad Faraz Anwar, Khalid Ahmed, Marziya Aftab, Fizza Nazim, Muhammad Furqan Bari, Mohammed Mustafa, Fahim Vohra, Ali Alrahlah, Nouman Mughal, Syed Hani Abidi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	MMP expression Periapical granuloma Periapical wound healing Surgical endodontic treatment Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/43c06d7ab0b04368b6675b332baf621e
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spelling	oai:doaj.org-article:43c06d7ab0b04368b6675b332baf621e2021-11-08T11:04:03ZBaseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment10.1186/s12903-021-01904-61472-6831https://doaj.org/article/43c06d7ab0b04368b6675b332baf621e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12903-021-01904-6https://doaj.org/toc/1472-6831Abstract Background Matrix metalloproteinases (MMPs) catalyzes the degradation of the extracellular matrix components and have a major role in many physiological processes including wound healing. In the current study, we examined the correlation of baseline MMPs 1, 2, 7, and 9 expressions with periapical wound healing after surgical endodontic treatment. Methods 27 patients aged between 15 and 57 years presenting with chronic apical periodontitis or chronic apical abscess of an anterior tooth with previously attempted or failed root canal treatment were included in this study. During surgical endodontic treatment, tissue from the periapical lesion sample was collected and used for gross histopathological analysis as well as mRNA expression analysis of MMPs 1, 2, 7, and 9. Patients were recalled for follow-up after 6 months to evaluate the healing status both clinically and radiographically and healing was correlated with baseline MMP expression. Results Out of 27 patients, healing was observed in 15 patients at the end of 6 months, and in 21 patients after 12 months.. Six patients showed no healing even after 12 months. Analysis of baseline MMP 1, 2, 7, and 9 expression levels with healing status showed the mean relative expression of MMP2 and MMP9 to be considerably increased in the non-healing group as compared to the healing group. Conclusion Overexpression of MMP2 and MMP9 may be considered as a potential prognostic biomarker for periapical wound healing after surgical endodontic treatment. However, further studies are desirable to establish its precise relationship with periapical wound healing.Muhammad Adeel AhmedMuhammad Faraz AnwarKhalid AhmedMarziya AftabFizza NazimMuhammad Furqan BariMohammed MustafaFahim VohraAli AlrahlahNouman MughalSyed Hani AbidiBMCarticleMMP expressionPeriapical granulomaPeriapical wound healingSurgical endodontic treatmentDentistryRK1-715ENBMC Oral Health, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MMP expression Periapical granuloma Periapical wound healing Surgical endodontic treatment Dentistry RK1-715
spellingShingle	MMP expression Periapical granuloma Periapical wound healing Surgical endodontic treatment Dentistry RK1-715 Muhammad Adeel Ahmed Muhammad Faraz Anwar Khalid Ahmed Marziya Aftab Fizza Nazim Muhammad Furqan Bari Mohammed Mustafa Fahim Vohra Ali Alrahlah Nouman Mughal Syed Hani Abidi Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
description	Abstract Background Matrix metalloproteinases (MMPs) catalyzes the degradation of the extracellular matrix components and have a major role in many physiological processes including wound healing. In the current study, we examined the correlation of baseline MMPs 1, 2, 7, and 9 expressions with periapical wound healing after surgical endodontic treatment. Methods 27 patients aged between 15 and 57 years presenting with chronic apical periodontitis or chronic apical abscess of an anterior tooth with previously attempted or failed root canal treatment were included in this study. During surgical endodontic treatment, tissue from the periapical lesion sample was collected and used for gross histopathological analysis as well as mRNA expression analysis of MMPs 1, 2, 7, and 9. Patients were recalled for follow-up after 6 months to evaluate the healing status both clinically and radiographically and healing was correlated with baseline MMP expression. Results Out of 27 patients, healing was observed in 15 patients at the end of 6 months, and in 21 patients after 12 months.. Six patients showed no healing even after 12 months. Analysis of baseline MMP 1, 2, 7, and 9 expression levels with healing status showed the mean relative expression of MMP2 and MMP9 to be considerably increased in the non-healing group as compared to the healing group. Conclusion Overexpression of MMP2 and MMP9 may be considered as a potential prognostic biomarker for periapical wound healing after surgical endodontic treatment. However, further studies are desirable to establish its precise relationship with periapical wound healing.
format	article
author	Muhammad Adeel Ahmed Muhammad Faraz Anwar Khalid Ahmed Marziya Aftab Fizza Nazim Muhammad Furqan Bari Mohammed Mustafa Fahim Vohra Ali Alrahlah Nouman Mughal Syed Hani Abidi
author_facet	Muhammad Adeel Ahmed Muhammad Faraz Anwar Khalid Ahmed Marziya Aftab Fizza Nazim Muhammad Furqan Bari Mohammed Mustafa Fahim Vohra Ali Alrahlah Nouman Mughal Syed Hani Abidi
author_sort	Muhammad Adeel Ahmed
title	Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
title_short	Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
title_full	Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
title_fullStr	Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
title_full_unstemmed	Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
title_sort	baseline mmp expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
publisher	BMC
publishDate	2021
url	https://doaj.org/article/43c06d7ab0b04368b6675b332baf621e
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Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment

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