Autophagy: a new target for nonalcoholic fatty liver disease therapy

Yuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mao YQ, Yu FJ, Wang JB, Guo CY, Fan XM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	nonalcoholic fatty liver disease autophagy steatosis steatohepatitis fibrosis carcinogenesis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/43c0996ee8ac44409b83bf36210489ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43c0996ee8ac44409b83bf36210489ed
record_format	dspace
spelling	oai:doaj.org-article:43c0996ee8ac44409b83bf36210489ed2021-12-02T07:59:09ZAutophagy: a new target for nonalcoholic fatty liver disease therapy1179-1535https://doaj.org/article/43c0996ee8ac44409b83bf36210489ed2016-03-01T00:00:00Zhttps://www.dovepress.com/autophagy-a-new-target-for-nonalcoholic-fatty-liver-disease-therapy-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Yuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department of Gastroenterology and Hepatology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, People's Republic of China Abstract: Nonalcoholic fatty liver disease (NAFLD) has gained importance in recent decades due to drastic changes in diet, especially in Western countries. NAFLD occurs as a spectrum from simple hepatic steatosis, steatohepatitis to cirrhosis, and even hepatocellular carcinoma. Although the molecular mechanisms underlying the development of NAFLD have been intensively investigated, many issues remain to be resolved. Autophagy is a cell survival mechanism for disposing of excess or defective organelles, and has become a hot spot for research. Recent studies have revealed that autophagy is linked to the development of NAFLD and regulation of autophagy has therapeutic potential. Autophagy reduces intracellular lipid droplets by enclosing them and fusing with lysosomes for degradation. Furthermore, autophagy is involved in attenuating inflammation and liver injury. However, autophagy is regarded as a double-edged sword, as it may also affect adipogenesis and adipocyte differentiation. Moreover, it is unclear as to whether autophagy protects the body from injury or causes diseases and even death, and the association between autophagy and NAFLD remains controversial. This review is intended to discuss, comment, and outline the progress made in this field and establish the possible molecular mechanism involved. Keywords: nonalcoholic fatty liver disease, autophagy, steatosis, steatohepatitis, fibrosis, carcinogenesisMao YQYu FJWang JBGuo CYFan XMDove Medical Pressarticlenonalcoholic fatty liver diseaseautophagysteatosissteatohepatitisfibrosiscarcinogenesisDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2016, Iss Issue 1, Pp 27-37 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonalcoholic fatty liver disease autophagy steatosis steatohepatitis fibrosis carcinogenesis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	nonalcoholic fatty liver disease autophagy steatosis steatohepatitis fibrosis carcinogenesis Diseases of the digestive system. Gastroenterology RC799-869 Mao YQ Yu FJ Wang JB Guo CY Fan XM Autophagy: a new target for nonalcoholic fatty liver disease therapy
description	Yuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department of Gastroenterology and Hepatology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, People's Republic of China Abstract: Nonalcoholic fatty liver disease (NAFLD) has gained importance in recent decades due to drastic changes in diet, especially in Western countries. NAFLD occurs as a spectrum from simple hepatic steatosis, steatohepatitis to cirrhosis, and even hepatocellular carcinoma. Although the molecular mechanisms underlying the development of NAFLD have been intensively investigated, many issues remain to be resolved. Autophagy is a cell survival mechanism for disposing of excess or defective organelles, and has become a hot spot for research. Recent studies have revealed that autophagy is linked to the development of NAFLD and regulation of autophagy has therapeutic potential. Autophagy reduces intracellular lipid droplets by enclosing them and fusing with lysosomes for degradation. Furthermore, autophagy is involved in attenuating inflammation and liver injury. However, autophagy is regarded as a double-edged sword, as it may also affect adipogenesis and adipocyte differentiation. Moreover, it is unclear as to whether autophagy protects the body from injury or causes diseases and even death, and the association between autophagy and NAFLD remains controversial. This review is intended to discuss, comment, and outline the progress made in this field and establish the possible molecular mechanism involved. Keywords: nonalcoholic fatty liver disease, autophagy, steatosis, steatohepatitis, fibrosis, carcinogenesis
format	article
author	Mao YQ Yu FJ Wang JB Guo CY Fan XM
author_facet	Mao YQ Yu FJ Wang JB Guo CY Fan XM
author_sort	Mao YQ
title	Autophagy: a new target for nonalcoholic fatty liver disease therapy
title_short	Autophagy: a new target for nonalcoholic fatty liver disease therapy
title_full	Autophagy: a new target for nonalcoholic fatty liver disease therapy
title_fullStr	Autophagy: a new target for nonalcoholic fatty liver disease therapy
title_full_unstemmed	Autophagy: a new target for nonalcoholic fatty liver disease therapy
title_sort	autophagy: a new target for nonalcoholic fatty liver disease therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/43c0996ee8ac44409b83bf36210489ed
work_keys_str_mv	AT maoyq autophagyanewtargetfornonalcoholicfattyliverdiseasetherapy AT yufj autophagyanewtargetfornonalcoholicfattyliverdiseasetherapy AT wangjb autophagyanewtargetfornonalcoholicfattyliverdiseasetherapy AT guocy autophagyanewtargetfornonalcoholicfattyliverdiseasetherapy AT fanxm autophagyanewtargetfornonalcoholicfattyliverdiseasetherapy
_version_	1718398718621777920

Autophagy: a new target for nonalcoholic fatty liver disease therapy

Ejemplares similares