Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower

Hibiscus manihot L. is a kind of healthy plant with edible value and health benefits, which possesses multiple pharmacological activities that are closely related to antioxidant and anti-inflammatory activities. The dynamic changes of main active components and biological activities in Hibiscus mani...

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Autores principales:	Ju-Zhao Liu, Chun-Chun Zhang, Yu-Jie Fu, Qi Cui
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Hibiscus manihot L. Harvest time Antioxidant activity Anti-inflammatory activity Phenolic compounds Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/43c1537e558446e2bf1c66aa6c2690ed
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spelling	oai:doaj.org-article:43c1537e558446e2bf1c66aa6c2690ed2021-11-04T04:27:45ZComparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower1878-535210.1016/j.arabjc.2021.103503https://doaj.org/article/43c1537e558446e2bf1c66aa6c2690ed2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005189https://doaj.org/toc/1878-5352Hibiscus manihot L. is a kind of healthy plant with edible value and health benefits, which possesses multiple pharmacological activities that are closely related to antioxidant and anti-inflammatory activities. The dynamic changes of main active components and biological activities in Hibiscus manihot L. flower (HMLF) during its flowering period were systematically studied to determine the appropriate harvest time. Chemopreventive efficacies of the investigated HMLF extracts, by means of their anti-inflammatory and antioxidant activities, were assessed. The sample harvested on early August had the supreme total flavonoid content, total phenolic content and the strongest antioxidant activity (DPPH radical scavenging activity (IC50 0.160 mg/mL), ABTS radical scavenging activity (1.570 mmol/g Trolox), reducing power (IC50 0.101 mg/mL) and FRAP (3.644 mmol FeSO4/g)). The results of principal component analysis indicated that the primary active components included hyperin, isoquercetin, hibifolin and quercetin-3′-O-glucoside, which were strongly associated with the antioxidant activity in the early August sample, while neochlorogenic acid, chlorogenic acid and caffeic acid were associated with the anti-inflammatory activity. The extracts significantly inhibited lipopolysaccharide-induced nitric oxide production in RAW264.7 cells, especially the samples harvested around August, which was only 3.569 μΜ with the inhibition ratio of>50%. This study indicated that HMLF harvested on the early August possessed the highest antioxidant and anti-inflammatory potential and could be used as high bioactive resources for healthy production.Ju-Zhao LiuChun-Chun ZhangYu-Jie FuQi CuiElsevierarticleHibiscus manihot L.Harvest timeAntioxidant activityAnti-inflammatory activityPhenolic compoundsChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 1, Pp 103503- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hibiscus manihot L. Harvest time Antioxidant activity Anti-inflammatory activity Phenolic compounds Chemistry QD1-999
spellingShingle	Hibiscus manihot L. Harvest time Antioxidant activity Anti-inflammatory activity Phenolic compounds Chemistry QD1-999 Ju-Zhao Liu Chun-Chun Zhang Yu-Jie Fu Qi Cui Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
description	Hibiscus manihot L. is a kind of healthy plant with edible value and health benefits, which possesses multiple pharmacological activities that are closely related to antioxidant and anti-inflammatory activities. The dynamic changes of main active components and biological activities in Hibiscus manihot L. flower (HMLF) during its flowering period were systematically studied to determine the appropriate harvest time. Chemopreventive efficacies of the investigated HMLF extracts, by means of their anti-inflammatory and antioxidant activities, were assessed. The sample harvested on early August had the supreme total flavonoid content, total phenolic content and the strongest antioxidant activity (DPPH radical scavenging activity (IC50 0.160 mg/mL), ABTS radical scavenging activity (1.570 mmol/g Trolox), reducing power (IC50 0.101 mg/mL) and FRAP (3.644 mmol FeSO4/g)). The results of principal component analysis indicated that the primary active components included hyperin, isoquercetin, hibifolin and quercetin-3′-O-glucoside, which were strongly associated with the antioxidant activity in the early August sample, while neochlorogenic acid, chlorogenic acid and caffeic acid were associated with the anti-inflammatory activity. The extracts significantly inhibited lipopolysaccharide-induced nitric oxide production in RAW264.7 cells, especially the samples harvested around August, which was only 3.569 μΜ with the inhibition ratio of>50%. This study indicated that HMLF harvested on the early August possessed the highest antioxidant and anti-inflammatory potential and could be used as high bioactive resources for healthy production.
format	article
author	Ju-Zhao Liu Chun-Chun Zhang Yu-Jie Fu Qi Cui
author_facet	Ju-Zhao Liu Chun-Chun Zhang Yu-Jie Fu Qi Cui
author_sort	Ju-Zhao Liu
title	Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
title_short	Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
title_full	Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
title_fullStr	Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
title_full_unstemmed	Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower
title_sort	comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from hibiscus manihot l. flower
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/43c1537e558446e2bf1c66aa6c2690ed
work_keys_str_mv	AT juzhaoliu comparativeanalysisofphytochemicalprofileantioxidantandantiinflammatoryactivityfromhibiscusmanihotlflower AT chunchunzhang comparativeanalysisofphytochemicalprofileantioxidantandantiinflammatoryactivityfromhibiscusmanihotlflower AT yujiefu comparativeanalysisofphytochemicalprofileantioxidantandantiinflammatoryactivityfromhibiscusmanihotlflower AT qicui comparativeanalysisofphytochemicalprofileantioxidantandantiinflammatoryactivityfromhibiscusmanihotlflower
_version_	1718445269967699968

Comparative analysis of phytochemical profile, antioxidant and anti-inflammatory activity from Hibiscus manihot L. flower

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