Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric cooperativity may contribute to the pathology that...

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Autores principales:	Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e
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spelling	oai:doaj.org-article:43c1fcd3a0854b83a040ab4779192c9e2021-12-02T13:34:31ZDefective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A10.1038/s42003-021-01819-62399-3642https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01819-6https://doaj.org/toc/2399-3642Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric cooperativity may contribute to the pathology that PKA-CDNAJB1 drives.Cristina OlivieriCaitlin WalkerAdak KaramafroozYingjie WangV. S. ManuFernando PorcelliDonald K. BlumenthalDavid D. ThomasDavid A. BernlohrSimon M. SandfordSusan S. TaylorGianluigi VegliaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Cristina Olivieri Caitlin Walker Adak Karamafrooz Yingjie Wang V. S. Manu Fernando Porcelli Donald K. Blumenthal David D. Thomas David A. Bernlohr Simon M. Sandford Susan S. Taylor Gianluigi Veglia Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
description	Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric cooperativity may contribute to the pathology that PKA-CDNAJB1 drives.
format	article
author	Cristina Olivieri Caitlin Walker Adak Karamafrooz Yingjie Wang V. S. Manu Fernando Porcelli Donald K. Blumenthal David D. Thomas David A. Bernlohr Simon M. Sandford Susan S. Taylor Gianluigi Veglia
author_facet	Cristina Olivieri Caitlin Walker Adak Karamafrooz Yingjie Wang V. S. Manu Fernando Porcelli Donald K. Blumenthal David D. Thomas David A. Bernlohr Simon M. Sandford Susan S. Taylor Gianluigi Veglia
author_sort	Cristina Olivieri
title	Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
title_short	Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
title_full	Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
title_fullStr	Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
title_full_unstemmed	Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
title_sort	defective internal allosteric network imparts dysfunctional atp/substrate-binding cooperativity in oncogenic chimera of protein kinase a
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e
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Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

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