Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit

Objective: To identify the possibility of alteration of intravenous (IV) to oral (PO) therapy for ampicillin/sulbactam and cefuroxime in adult patients treated in intensive care units (ICUs), and to describe the profile and consumption of antimicrobials prescribed for these patients. Methods: A des...

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Autores principales:	Deise L. LOCATELLI, Carine R. BLATT, Maria C. WERLANG
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/43c228d28980434b9df8757845532380
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spelling	oai:doaj.org-article:43c228d28980434b9df87578455323802021-11-28T02:44:48ZConversion of intravenous to oral antibiotic therapy in an adult intensive care unit10.30968/rbfhss.2020.113.04442179-59242316-7750https://doaj.org/article/43c228d28980434b9df87578455323802020-08-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/444https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objective: To identify the possibility of alteration of intravenous (IV) to oral (PO) therapy for ampicillin/sulbactam and cefuroxime in adult patients treated in intensive care units (ICUs), and to describe the profile and consumption of antimicrobials prescribed for these patients. Methods: A descriptive, cross-sectional, and retrospective documentary study based on the analysis of electronic prescriptions and data from the electronic medical record of patients admitted to adult intensive care units in two hospitals, from July to August 2019. The consumption of antimicrobials was measured using the Anatomical Therapeutic Chemical/Daily Defined Dose (ATC/DDD) methodology per 100 beds-day. Results: Of the patients admitted to the study units, 23 (5.5%) received ampicillin/sulbactam or cefuroxime; the time of the ampicillin/sulbactam treatment was 7.25 (±2.07) days and, with cefuroxime, 8 (±1.73) days; 3 (13%) of the patients followed were eligible to switch therapy or sequential therapy, there was no physician acceptance of the conversion recommendation. The highest consumption was observed in the penicillins therapeutic group (112.5 DDD/100 beds-day) and meropenem drug (68.8 DDD/100 beds-day). Conclusions: Antimicrobial use is high in ICUs, which can be related to the clinical complexity and to the microbiological profile of the patients. The practice of converting IV antibiotic therapy to PO in critically ill patients was not present in this study; however, its use can contribute to patient safety. Deise L. LOCATELLICarine R. BLATTMaria C. WERLANGSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 11, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Deise L. LOCATELLI Carine R. BLATT Maria C. WERLANG Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
description	Objective: To identify the possibility of alteration of intravenous (IV) to oral (PO) therapy for ampicillin/sulbactam and cefuroxime in adult patients treated in intensive care units (ICUs), and to describe the profile and consumption of antimicrobials prescribed for these patients. Methods: A descriptive, cross-sectional, and retrospective documentary study based on the analysis of electronic prescriptions and data from the electronic medical record of patients admitted to adult intensive care units in two hospitals, from July to August 2019. The consumption of antimicrobials was measured using the Anatomical Therapeutic Chemical/Daily Defined Dose (ATC/DDD) methodology per 100 beds-day. Results: Of the patients admitted to the study units, 23 (5.5%) received ampicillin/sulbactam or cefuroxime; the time of the ampicillin/sulbactam treatment was 7.25 (±2.07) days and, with cefuroxime, 8 (±1.73) days; 3 (13%) of the patients followed were eligible to switch therapy or sequential therapy, there was no physician acceptance of the conversion recommendation. The highest consumption was observed in the penicillins therapeutic group (112.5 DDD/100 beds-day) and meropenem drug (68.8 DDD/100 beds-day). Conclusions: Antimicrobial use is high in ICUs, which can be related to the clinical complexity and to the microbiological profile of the patients. The practice of converting IV antibiotic therapy to PO in critically ill patients was not present in this study; however, its use can contribute to patient safety.
format	article
author	Deise L. LOCATELLI Carine R. BLATT Maria C. WERLANG
author_facet	Deise L. LOCATELLI Carine R. BLATT Maria C. WERLANG
author_sort	Deise L. LOCATELLI
title	Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
title_short	Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
title_full	Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
title_fullStr	Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
title_full_unstemmed	Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
title_sort	conversion of intravenous to oral antibiotic therapy in an adult intensive care unit
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/43c228d28980434b9df8757845532380
work_keys_str_mv	AT deisellocatelli conversionofintravenoustooralantibiotictherapyinanadultintensivecareunit AT carinerblatt conversionofintravenoustooralantibiotictherapyinanadultintensivecareunit AT mariacwerlang conversionofintravenoustooralantibiotictherapyinanadultintensivecareunit
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Conversion of intravenous to oral antibiotic therapy in an adult intensive care unit

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