Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.

Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.

<h4>Background</h4>Genome-wide association studies have identified susceptibility genes for development of type 2 diabetes. We aimed to examine whether a subset of these (comprising FTO, IDE, KCNJ11, PPARG and TCF7L2) were transcriptionally restricted to or enriched in human beta cells b...

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Autores principales: Clare L Kirkpatrick, Piero Marchetti, Francesco Purrello, Salvatore Piro, Marco Bugliani, Domenico Bosco, Eelco J P de Koning, Marten A Engelse, Julie Kerr-Conte, François Pattou, Claes B Wollheim
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/43c3c62a4a324538b6f4bf1ca4d663b2
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