The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence

Abstract Stimuli previously paired with drugs of dependence can produce cravings that are associated with increased dopamine (DA) levels in limbic and striatal brain areas. Positron Emission Tomography (PET) imaging with [11C]-(+)-PHNO allows for a sensitive measurement of changes in DA levels. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Patricia Di Ciano, Harriet de Wit, Esmaeil Mansouri, Sylvain Houle, Isabelle Boileau, Bernard Le Foll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43c3cb03aec84e3ea43938674f3d4922
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43c3cb03aec84e3ea43938674f3d4922
record_format	dspace
spelling	oai:doaj.org-article:43c3cb03aec84e3ea43938674f3d49222021-12-02T15:57:11ZThe influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence10.1038/s41598-021-90915-y2045-2322https://doaj.org/article/43c3cb03aec84e3ea43938674f3d49222021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90915-yhttps://doaj.org/toc/2045-2322Abstract Stimuli previously paired with drugs of dependence can produce cravings that are associated with increased dopamine (DA) levels in limbic and striatal brain areas. Positron Emission Tomography (PET) imaging with [11C]-(+)-PHNO allows for a sensitive measurement of changes in DA levels. The purpose of the present study was to investigate changes in DA levels, measured with PET imaging with [11C]-(+)-PHNO, in regions of interest in smokers who had maintained abstinence for 7–10 days. Participants (N = 10) underwent two PET scans on separate days, during which they viewed either smoking-related or neutral images, in counterbalanced order. Craving was measured with the 12-item Tobacco Craving Questionnaire (TCQ) and the Questionnaire on Smoking Urges-Brief (QSU-B). Compared to neutral cues, smoking cues did not increase craving. There were no changes in [11C]-(+)-PHNO binding in the cue condition compared to the neutral condition for most regions of interest (ventral pallidum, globus pallidus, limbic striatum, associative striatum, sensorimotor striatum). However, binding potential in the substantia nigra was greater in the smoking-cue condition, indicating decreased synaptic dopamine. There is a potential change of DA level occurring in midbrain following the presentation of smoking-related cues. However, this preliminary finding would need to be validated with a larger sample.Patricia Di CianoHarriet de WitEsmaeil MansouriSylvain HouleIsabelle BoileauBernard Le FollNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patricia Di Ciano Harriet de Wit Esmaeil Mansouri Sylvain Houle Isabelle Boileau Bernard Le Foll The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
description	Abstract Stimuli previously paired with drugs of dependence can produce cravings that are associated with increased dopamine (DA) levels in limbic and striatal brain areas. Positron Emission Tomography (PET) imaging with [11C]-(+)-PHNO allows for a sensitive measurement of changes in DA levels. The purpose of the present study was to investigate changes in DA levels, measured with PET imaging with [11C]-(+)-PHNO, in regions of interest in smokers who had maintained abstinence for 7–10 days. Participants (N = 10) underwent two PET scans on separate days, during which they viewed either smoking-related or neutral images, in counterbalanced order. Craving was measured with the 12-item Tobacco Craving Questionnaire (TCQ) and the Questionnaire on Smoking Urges-Brief (QSU-B). Compared to neutral cues, smoking cues did not increase craving. There were no changes in [11C]-(+)-PHNO binding in the cue condition compared to the neutral condition for most regions of interest (ventral pallidum, globus pallidus, limbic striatum, associative striatum, sensorimotor striatum). However, binding potential in the substantia nigra was greater in the smoking-cue condition, indicating decreased synaptic dopamine. There is a potential change of DA level occurring in midbrain following the presentation of smoking-related cues. However, this preliminary finding would need to be validated with a larger sample.
format	article
author	Patricia Di Ciano Harriet de Wit Esmaeil Mansouri Sylvain Houle Isabelle Boileau Bernard Le Foll
author_facet	Patricia Di Ciano Harriet de Wit Esmaeil Mansouri Sylvain Houle Isabelle Boileau Bernard Le Foll
author_sort	Patricia Di Ciano
title	The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
title_short	The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
title_full	The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
title_fullStr	The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
title_full_unstemmed	The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence
title_sort	influence of conditioned stimuli on [11c]-(+)-phno pet binding in tobacco smokers after a one week abstinence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43c3cb03aec84e3ea43938674f3d4922
work_keys_str_mv	AT patriciadiciano theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT harrietdewit theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT esmaeilmansouri theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT sylvainhoule theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT isabelleboileau theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT bernardlefoll theinfluenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT patriciadiciano influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT harrietdewit influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT esmaeilmansouri influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT sylvainhoule influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT isabelleboileau influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence AT bernardlefoll influenceofconditionedstimulion11cphnopetbindingintobaccosmokersafteraoneweekabstinence
_version_	1718385325171015680

The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence

Ejemplares similares