TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress...

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Autores principales:	Rose Willett, José A. Martina, James P. Zewe, Rachel Wills, Gerald R. V. Hammond, Rosa Puertollano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43c5b38261d14c7e8511b4224b04b132
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spelling	oai:doaj.org-article:43c5b38261d14c7e8511b4224b04b1322021-12-02T15:39:05ZTFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes10.1038/s41467-017-01871-z2041-1723https://doaj.org/article/43c5b38261d14c7e8511b4224b04b1322017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01871-zhttps://doaj.org/toc/2041-1723Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.Rose WillettJosé A. MartinaJames P. ZeweRachel WillsGerald R. V. HammondRosa PuertollanoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rose Willett José A. Martina James P. Zewe Rachel Wills Gerald R. V. Hammond Rosa Puertollano TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
description	Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.
format	article
author	Rose Willett José A. Martina James P. Zewe Rachel Wills Gerald R. V. Hammond Rosa Puertollano
author_facet	Rose Willett José A. Martina James P. Zewe Rachel Wills Gerald R. V. Hammond Rosa Puertollano
author_sort	Rose Willett
title	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_short	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_full	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_fullStr	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_full_unstemmed	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_sort	tfeb regulates lysosomal positioning by modulating tmem55b expression and jip4 recruitment to lysosomes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43c5b38261d14c7e8511b4224b04b132
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TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

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