TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress...

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Autores principales: Rose Willett, José A. Martina, James P. Zewe, Rachel Wills, Gerald R. V. Hammond, Rosa Puertollano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/43c5b38261d14c7e8511b4224b04b132
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