Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.

The molecular mechanism that controls the proliferation and differentiation of prostate epithelial cells is currently unknown. We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting protein that regulates a set of androgen receptor target genes in prostate epitheli...

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Autores principales:	Shen Gao, Zhengxin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43cb0b0ec4fa453dbf22e8aa1fee0cbb
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spelling	oai:doaj.org-article:43cb0b0ec4fa453dbf22e8aa1fee0cbb2021-11-18T08:09:21ZSubcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.1932-620310.1371/journal.pone.0049173https://doaj.org/article/43cb0b0ec4fa453dbf22e8aa1fee0cbb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145110/?tool=EBIhttps://doaj.org/toc/1932-6203The molecular mechanism that controls the proliferation and differentiation of prostate epithelial cells is currently unknown. We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting protein that regulates a set of androgen receptor target genes in prostate epithelial cells and prostate cancer. In this study, we found that p44 localizes in the cytoplasm of prostate epithelial cells at the early stage of prostate development when cells are proliferating, and its nuclear translocation is associated with cellular and functional differentiation in adult prostate tissue. We further demonstrated that cytoplasmic p44 protein is essential for proliferation of prostate epithelial cells, whereas nuclear p44 is required for cell differentiation and prostate- specific protein secretion. These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by p44's location in the cell.Shen GaoZhengxin WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49173 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shen Gao Zhengxin Wang Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
description	The molecular mechanism that controls the proliferation and differentiation of prostate epithelial cells is currently unknown. We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting protein that regulates a set of androgen receptor target genes in prostate epithelial cells and prostate cancer. In this study, we found that p44 localizes in the cytoplasm of prostate epithelial cells at the early stage of prostate development when cells are proliferating, and its nuclear translocation is associated with cellular and functional differentiation in adult prostate tissue. We further demonstrated that cytoplasmic p44 protein is essential for proliferation of prostate epithelial cells, whereas nuclear p44 is required for cell differentiation and prostate- specific protein secretion. These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by p44's location in the cell.
format	article
author	Shen Gao Zhengxin Wang
author_facet	Shen Gao Zhengxin Wang
author_sort	Shen Gao
title	Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
title_short	Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
title_full	Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
title_fullStr	Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
title_full_unstemmed	Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
title_sort	subcellular localization of p44/wdr77 determines proliferation and differentiation of prostate epithelial cells.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/43cb0b0ec4fa453dbf22e8aa1fee0cbb
work_keys_str_mv	AT shengao subcellularlocalizationofp44wdr77determinesproliferationanddifferentiationofprostateepithelialcells AT zhengxinwang subcellularlocalizationofp44wdr77determinesproliferationanddifferentiationofprostateepithelialcells
_version_	1718422102021767168

Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.

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