Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycoside...

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Autores principales:	Anshul Sharma, Hyo-Kyoung Choi, Yeon-Kye Kim, Hae-Jeung Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	delphinidin cancer proliferation metastasis anthocyanidins anthocyanins Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/43cb8d526eec441582d856eb50025d08
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spelling	oai:doaj.org-article:43cb8d526eec441582d856eb50025d082021-11-11T16:57:47ZDelphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives10.3390/ijms2221115001422-00671661-6596https://doaj.org/article/43cb8d526eec441582d856eb50025d082021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11500https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.Anshul SharmaHyo-Kyoung ChoiYeon-Kye KimHae-Jeung LeeMDPI AGarticledelphinidincancerproliferationmetastasisanthocyanidinsanthocyaninsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11500, p 11500 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	delphinidin cancer proliferation metastasis anthocyanidins anthocyanins Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	delphinidin cancer proliferation metastasis anthocyanidins anthocyanins Biology (General) QH301-705.5 Chemistry QD1-999 Anshul Sharma Hyo-Kyoung Choi Yeon-Kye Kim Hae-Jeung Lee Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
description	Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.
format	article
author	Anshul Sharma Hyo-Kyoung Choi Yeon-Kye Kim Hae-Jeung Lee
author_facet	Anshul Sharma Hyo-Kyoung Choi Yeon-Kye Kim Hae-Jeung Lee
author_sort	Anshul Sharma
title	Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
title_short	Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
title_full	Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
title_fullStr	Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
title_full_unstemmed	Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives
title_sort	delphinidin and its glycosides’ war on cancer: preclinical perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/43cb8d526eec441582d856eb50025d08
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Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

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