Drug target gene-based analyses of drug repositionability in rare and intractable diseases

Abstract Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development. We aimed to analyze the trend of drug reposi...

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Autores principales:	Ryuichi Sakate, Tomonori Kimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43ce3b52f56b4575b6624b17c048893f
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spelling	oai:doaj.org-article:43ce3b52f56b4575b6624b17c048893f2021-12-02T14:58:20ZDrug target gene-based analyses of drug repositionability in rare and intractable diseases10.1038/s41598-021-91428-42045-2322https://doaj.org/article/43ce3b52f56b4575b6624b17c048893f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91428-4https://doaj.org/toc/2045-2322Abstract Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development. We aimed to analyze the trend of drug repositioning and inter-disease drug repositionability among rare and intractable diseases. We created a list of rare and intractable diseases based on the designated diseases in Japan. Drug information extracted from clinical trial data were integrated with information of drug target genes, which represent the mechanism of drug action. We obtained 753 drugs and 551 drug target genes from 8307 clinical trials for 189 diseases or disease groups. Trend analysis of drug sharing between a disease pair revealed that 1676 drug repositioning events occurred in 4401 disease pairs. A score, R gene, was invented to investigate the proportion of drug target genes shared between a disease pair. Annual changes of R gene corresponded to the trend of drug repositioning and predicted drug repositioning events occurring within a year or two. Drug target gene-based analyses well visualized the drug repositioning landscape. This approach facilitates drug development for rare and intractable diseases.Ryuichi SakateTomonori KimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryuichi Sakate Tomonori Kimura Drug target gene-based analyses of drug repositionability in rare and intractable diseases
description	Abstract Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development. We aimed to analyze the trend of drug repositioning and inter-disease drug repositionability among rare and intractable diseases. We created a list of rare and intractable diseases based on the designated diseases in Japan. Drug information extracted from clinical trial data were integrated with information of drug target genes, which represent the mechanism of drug action. We obtained 753 drugs and 551 drug target genes from 8307 clinical trials for 189 diseases or disease groups. Trend analysis of drug sharing between a disease pair revealed that 1676 drug repositioning events occurred in 4401 disease pairs. A score, R gene, was invented to investigate the proportion of drug target genes shared between a disease pair. Annual changes of R gene corresponded to the trend of drug repositioning and predicted drug repositioning events occurring within a year or two. Drug target gene-based analyses well visualized the drug repositioning landscape. This approach facilitates drug development for rare and intractable diseases.
format	article
author	Ryuichi Sakate Tomonori Kimura
author_facet	Ryuichi Sakate Tomonori Kimura
author_sort	Ryuichi Sakate
title	Drug target gene-based analyses of drug repositionability in rare and intractable diseases
title_short	Drug target gene-based analyses of drug repositionability in rare and intractable diseases
title_full	Drug target gene-based analyses of drug repositionability in rare and intractable diseases
title_fullStr	Drug target gene-based analyses of drug repositionability in rare and intractable diseases
title_full_unstemmed	Drug target gene-based analyses of drug repositionability in rare and intractable diseases
title_sort	drug target gene-based analyses of drug repositionability in rare and intractable diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43ce3b52f56b4575b6624b17c048893f
work_keys_str_mv	AT ryuichisakate drugtargetgenebasedanalysesofdrugrepositionabilityinrareandintractablediseases AT tomonorikimura drugtargetgenebasedanalysesofdrugrepositionabilityinrareandintractablediseases
_version_	1718389261617594368

Drug target gene-based analyses of drug repositionability in rare and intractable diseases

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