An update on belimumab for the treatment of lupus
Aikaterini Thanou-Stavraki1, Amr H Sawalha1,2,31Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA; 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation,...
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Dove Medical Press
2011
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oai:doaj.org-article:43cfec6a19964edf89dc927927f1a5872021-12-02T00:13:38ZAn update on belimumab for the treatment of lupus1177-54751177-5491https://doaj.org/article/43cfec6a19964edf89dc927927f1a5872011-02-01T00:00:00Zhttp://www.dovepress.com/an-update-on-belimumab-for-the-treatment-of-lupus-a6313https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Aikaterini Thanou-Stavraki1, Amr H Sawalha1,2,31Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA; 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USAAbstract: B-lymphocyte stimulator (BLyS), a homeostatic factor for B-cell differentiation and survival, has a major role in B-cell expansion and autoreactivity that characterize systemic lupus erythematosus (SLE). Belimumab, a BLyS-specific inhibitor, has shown promising evidence of efficacy in several preclinical and clinical studies in SLE. Two recent large randomized controlled trials yielded a significant positive effect of the drug compared to placebo in patients with active disease. In this review, we discuss basic aspects of B-cell and BLyS biology in SLE and summarize the evidence supporting a role of belimumab in SLE, from animal studies to phase III clinical trials.Keywords: B lymphocyte stimulator, lupus erythematosus, belimumab Aikaterini Thanou-StavrakiAmr H SawalhaDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2011, Iss default, Pp 33-43 (2011) |
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DOAJ |
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DOAJ |
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EN |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Aikaterini Thanou-Stavraki Amr H Sawalha An update on belimumab for the treatment of lupus |
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Aikaterini Thanou-Stavraki1, Amr H Sawalha1,2,31Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA; 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USAAbstract: B-lymphocyte stimulator (BLyS), a homeostatic factor for B-cell differentiation and survival, has a major role in B-cell expansion and autoreactivity that characterize systemic lupus erythematosus (SLE). Belimumab, a BLyS-specific inhibitor, has shown promising evidence of efficacy in several preclinical and clinical studies in SLE. Two recent large randomized controlled trials yielded a significant positive effect of the drug compared to placebo in patients with active disease. In this review, we discuss basic aspects of B-cell and BLyS biology in SLE and summarize the evidence supporting a role of belimumab in SLE, from animal studies to phase III clinical trials.Keywords: B lymphocyte stimulator, lupus erythematosus, belimumab |
| format |
article |
| author |
Aikaterini Thanou-Stavraki Amr H Sawalha |
| author_facet |
Aikaterini Thanou-Stavraki Amr H Sawalha |
| author_sort |
Aikaterini Thanou-Stavraki |
| title |
An update on belimumab for the treatment of lupus |
| title_short |
An update on belimumab for the treatment of lupus |
| title_full |
An update on belimumab for the treatment of lupus |
| title_fullStr |
An update on belimumab for the treatment of lupus |
| title_full_unstemmed |
An update on belimumab for the treatment of lupus |
| title_sort |
update on belimumab for the treatment of lupus |
| publisher |
Dove Medical Press |
| publishDate |
2011 |
| url |
https://doaj.org/article/43cfec6a19964edf89dc927927f1a587 |
| work_keys_str_mv |
AT aikaterinithanoustavraki anupdateonbelimumabforthetreatmentoflupus AT amrhsawalha anupdateonbelimumabforthetreatmentoflupus AT aikaterinithanoustavraki updateonbelimumabforthetreatmentoflupus AT amrhsawalha updateonbelimumabforthetreatmentoflupus |
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