New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silve...

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Autores principales:	Mocanu A, Pasca RD, Tomoaia G, Garbo C, Frangopol PT, Horovitz O, Tomoaia-Cotisel M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/43dd1b5264f34a8685b39183eedc8fab
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spelling	oai:doaj.org-article:43dd1b5264f34a8685b39183eedc8fab2021-12-02T07:22:59ZNew procedure to synthesize silver nanoparticles and their interaction with local anesthetics1176-91141178-2013https://doaj.org/article/43dd1b5264f34a8685b39183eedc8fab2013-10-01T00:00:00Zhttp://www.dovepress.com/new-procedure-to-synthesize-silver-nanoparticles-and-their-interaction-a14636https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silver nanoparticles (AgNPs) were prepared in aqueous colloid dispersions by the reduction of Ag+ with glucose in alkaline medium. Tetraethyl orthosilicate and l-asparagine were added as stabilizers of NPs. The AgNPs were characterized, and their interaction with three local anesthetics (procaine, dibucaine, or tetracaine) was investigated. Optical spectra show the characteristic absorption band of AgNPs, due to surface plasmon resonance. Modifications in the position and shape of this band reflect the self-assembly of metal NPs mediated by anesthetic molecules and the progress in time of the aggregation process. Zeta-potential measuring was applied in order to characterize the electrostatic stability of the NPs. The size and shape of the AgNPs, as well as the features of the assemblies formed by their association in the presence of anesthetics, were evidenced by transmission electron microscopy images. Atomic force microscopy images showed the characteristics of the films of AgNPs deposited on glass support. The effect of the anesthetics could be described in terms of electrostatic forces between the negatively charged AgNPs and the anesthetic molecules, existing also in their cationic form at the working pH. But also hydrophobic and hydrogen bonding interactions between the coated nanoparticles and anesthetics molecular species should be considered.Keywords: self-assembled nanostructures, UV-vis spectra, TEM, AFM, zeta potentialMocanu APasca RDTomoaia GGarbo CFrangopol PTHorovitz OTomoaia-Cotisel MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3867-3874 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mocanu A Pasca RD Tomoaia G Garbo C Frangopol PT Horovitz O Tomoaia-Cotisel M New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
description	Aurora Mocanu,1 Roxana Diana Pasca,1 Gheorghe Tomoaia,2 Corina Garbo,1 Petre T Frangopol,1 Ossi Horovitz,1 Maria Tomoaia-Cotisel11Chemical Engineering Department, Babes-Bolyai University, 2Orthopedic Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: Silver nanoparticles (AgNPs) were prepared in aqueous colloid dispersions by the reduction of Ag+ with glucose in alkaline medium. Tetraethyl orthosilicate and l-asparagine were added as stabilizers of NPs. The AgNPs were characterized, and their interaction with three local anesthetics (procaine, dibucaine, or tetracaine) was investigated. Optical spectra show the characteristic absorption band of AgNPs, due to surface plasmon resonance. Modifications in the position and shape of this band reflect the self-assembly of metal NPs mediated by anesthetic molecules and the progress in time of the aggregation process. Zeta-potential measuring was applied in order to characterize the electrostatic stability of the NPs. The size and shape of the AgNPs, as well as the features of the assemblies formed by their association in the presence of anesthetics, were evidenced by transmission electron microscopy images. Atomic force microscopy images showed the characteristics of the films of AgNPs deposited on glass support. The effect of the anesthetics could be described in terms of electrostatic forces between the negatively charged AgNPs and the anesthetic molecules, existing also in their cationic form at the working pH. But also hydrophobic and hydrogen bonding interactions between the coated nanoparticles and anesthetics molecular species should be considered.Keywords: self-assembled nanostructures, UV-vis spectra, TEM, AFM, zeta potential
format	article
author	Mocanu A Pasca RD Tomoaia G Garbo C Frangopol PT Horovitz O Tomoaia-Cotisel M
author_facet	Mocanu A Pasca RD Tomoaia G Garbo C Frangopol PT Horovitz O Tomoaia-Cotisel M
author_sort	Mocanu A
title	New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
title_short	New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
title_full	New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
title_fullStr	New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
title_full_unstemmed	New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
title_sort	new procedure to synthesize silver nanoparticles and their interaction with local anesthetics
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/43dd1b5264f34a8685b39183eedc8fab
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New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

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