General structural features that regulate integrin affinity revealed by atypical αVβ8

The activation mechanism of integrin αVβ8 differs from other integrins. Combining X-ray crystallography, hydrogen deuterium exchange mass spectrometry and mutation, the authors reveal structural features responsible for these differences and provide insights into how typical integrins are regulated....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jianchuan Wang, Yang Su, Roxana E. Iacob, John R. Engen, Timothy A. Springer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43de20468235470690fca07f6b07b53e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43de20468235470690fca07f6b07b53e
record_format	dspace
spelling	oai:doaj.org-article:43de20468235470690fca07f6b07b53e2021-12-02T14:40:21ZGeneral structural features that regulate integrin affinity revealed by atypical αVβ810.1038/s41467-019-13248-52041-1723https://doaj.org/article/43de20468235470690fca07f6b07b53e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13248-5https://doaj.org/toc/2041-1723The activation mechanism of integrin αVβ8 differs from other integrins. Combining X-ray crystallography, hydrogen deuterium exchange mass spectrometry and mutation, the authors reveal structural features responsible for these differences and provide insights into how typical integrins are regulated.Jianchuan WangYang SuRoxana E. IacobJohn R. EngenTimothy A. SpringerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianchuan Wang Yang Su Roxana E. Iacob John R. Engen Timothy A. Springer General structural features that regulate integrin affinity revealed by atypical αVβ8
description	The activation mechanism of integrin αVβ8 differs from other integrins. Combining X-ray crystallography, hydrogen deuterium exchange mass spectrometry and mutation, the authors reveal structural features responsible for these differences and provide insights into how typical integrins are regulated.
format	article
author	Jianchuan Wang Yang Su Roxana E. Iacob John R. Engen Timothy A. Springer
author_facet	Jianchuan Wang Yang Su Roxana E. Iacob John R. Engen Timothy A. Springer
author_sort	Jianchuan Wang
title	General structural features that regulate integrin affinity revealed by atypical αVβ8
title_short	General structural features that regulate integrin affinity revealed by atypical αVβ8
title_full	General structural features that regulate integrin affinity revealed by atypical αVβ8
title_fullStr	General structural features that regulate integrin affinity revealed by atypical αVβ8
title_full_unstemmed	General structural features that regulate integrin affinity revealed by atypical αVβ8
title_sort	general structural features that regulate integrin affinity revealed by atypical αvβ8
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/43de20468235470690fca07f6b07b53e
work_keys_str_mv	AT jianchuanwang generalstructuralfeaturesthatregulateintegrinaffinityrevealedbyatypicalavb8 AT yangsu generalstructuralfeaturesthatregulateintegrinaffinityrevealedbyatypicalavb8 AT roxanaeiacob generalstructuralfeaturesthatregulateintegrinaffinityrevealedbyatypicalavb8 AT johnrengen generalstructuralfeaturesthatregulateintegrinaffinityrevealedbyatypicalavb8 AT timothyaspringer generalstructuralfeaturesthatregulateintegrinaffinityrevealedbyatypicalavb8
_version_	1718390290561105920

General structural features that regulate integrin affinity revealed by atypical αVβ8

Ejemplares similares