General structural features that regulate integrin affinity revealed by atypical αVβ8
The activation mechanism of integrin αVβ8 differs from other integrins. Combining X-ray crystallography, hydrogen deuterium exchange mass spectrometry and mutation, the authors reveal structural features responsible for these differences and provide insights into how typical integrins are regulated....
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Autores principales: | Jianchuan Wang, Yang Su, Roxana E. Iacob, John R. Engen, Timothy A. Springer |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/43de20468235470690fca07f6b07b53e |
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