Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>

Oleuropein (OLE) is a secoiridoid glycoside that mainly exists in olives with multifaceted health benefits. The present study aimed to investigate the stress resistance and lifespan extension effects of OLE in <i>Caenorhabditis elegans</i>. The results showed that OLE could significantly...

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Autores principales:	Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oleuropein <i>Caenorhabditis elegans</i> longevity stress resistance Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/43df9a24c9fd4f42838a20840e397528
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spelling	oai:doaj.org-article:43df9a24c9fd4f42838a20840e3975282021-11-25T16:26:28ZOleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>10.3390/antiox101116972076-3921https://doaj.org/article/43df9a24c9fd4f42838a20840e3975282021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1697https://doaj.org/toc/2076-3921Oleuropein (OLE) is a secoiridoid glycoside that mainly exists in olives with multifaceted health benefits. The present study aimed to investigate the stress resistance and lifespan extension effects of OLE in <i>Caenorhabditis elegans</i>. The results showed that OLE could significantly prolong the lifespan of <i>C. elegans</i> by 22.29%. Treatment with OLE also significantly increased the survival rates of worms against lethal heat shock and oxidative stress. Meanwhile, OLE supplementation increased the expression and activity of antioxidant enzymes and suppressed the generation of malondialdehyde in nematodes. In addition, the results from mutants implied that OLE might mediate longevity and stress resistance via DAF-16/FoxO, which played a vital role in the insulin/IGF-1 signaling (IIS) pathway. To further identify the molecular targets of OLE, mRNA level and loss-of-function mutants of IIS-associated genes were investigated. The data revealed that OLE activated IIS by down-regulating the upstream components, <i>daf-2</i> and <i>age-1</i>. Furthermore, another stress response and longevity pathway in parallel to DAF-16, SKN-1/Nrf2, was also shown to involve in OLE-induced beneficial effects. Collectively, these results provide the theoretical basis that OLE could enhance the stress resistance and increase the lifespan of <i>C. elegans</i> through the IIS and SKN-1/Nrf2 signaling pathways.Shiling FengChunyan ZhangTao ChenLijun ZhouYan HuangMing YuanTian LiChunbang DingMDPI AGarticleoleuropein<i>Caenorhabditis elegans</i>longevitystress resistanceTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1697, p 1697 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oleuropein <i>Caenorhabditis elegans</i> longevity stress resistance Therapeutics. Pharmacology RM1-950
spellingShingle	oleuropein <i>Caenorhabditis elegans</i> longevity stress resistance Therapeutics. Pharmacology RM1-950 Shiling Feng Chunyan Zhang Tao Chen Lijun Zhou Yan Huang Ming Yuan Tian Li Chunbang Ding Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
description	Oleuropein (OLE) is a secoiridoid glycoside that mainly exists in olives with multifaceted health benefits. The present study aimed to investigate the stress resistance and lifespan extension effects of OLE in <i>Caenorhabditis elegans</i>. The results showed that OLE could significantly prolong the lifespan of <i>C. elegans</i> by 22.29%. Treatment with OLE also significantly increased the survival rates of worms against lethal heat shock and oxidative stress. Meanwhile, OLE supplementation increased the expression and activity of antioxidant enzymes and suppressed the generation of malondialdehyde in nematodes. In addition, the results from mutants implied that OLE might mediate longevity and stress resistance via DAF-16/FoxO, which played a vital role in the insulin/IGF-1 signaling (IIS) pathway. To further identify the molecular targets of OLE, mRNA level and loss-of-function mutants of IIS-associated genes were investigated. The data revealed that OLE activated IIS by down-regulating the upstream components, <i>daf-2</i> and <i>age-1</i>. Furthermore, another stress response and longevity pathway in parallel to DAF-16, SKN-1/Nrf2, was also shown to involve in OLE-induced beneficial effects. Collectively, these results provide the theoretical basis that OLE could enhance the stress resistance and increase the lifespan of <i>C. elegans</i> through the IIS and SKN-1/Nrf2 signaling pathways.
format	article
author	Shiling Feng Chunyan Zhang Tao Chen Lijun Zhou Yan Huang Ming Yuan Tian Li Chunbang Ding
author_facet	Shiling Feng Chunyan Zhang Tao Chen Lijun Zhou Yan Huang Ming Yuan Tian Li Chunbang Ding
author_sort	Shiling Feng
title	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
title_short	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
title_full	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
title_fullStr	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
title_full_unstemmed	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>
title_sort	oleuropein enhances stress resistance and extends lifespan via insulin/igf-1 and skn-1/nrf2 signaling pathway in <i>caenorhabditis elegans</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/43df9a24c9fd4f42838a20840e397528
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Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in <i>Caenorhabditis elegans</i>

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