Abnormal whole-brain functional connectivity in patients with primary insomnia

Chao Li, Mengshi Dong, Yi Yin, Kelei Hua, Shishun Fu, Guihua Jiang Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, Guangz...

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Autores principales:	Li C, Dong M, Yin Y, Hua K, Fu S, Jiang G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	primary insomnia hyperarousal hypothesis resting-state fMRI functional connectivity whole-brain. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/43e257a72420487e8ced0d6590dcf8d5
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spelling	oai:doaj.org-article:43e257a72420487e8ced0d6590dcf8d52021-12-02T06:36:28ZAbnormal whole-brain functional connectivity in patients with primary insomnia1178-2021https://doaj.org/article/43e257a72420487e8ced0d6590dcf8d52017-02-01T00:00:00Zhttps://www.dovepress.com/abnormal-whole-brain-functional-connectivity-in-patients-with-primary--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chao Li, Mengshi Dong, Yi Yin, Kelei Hua, Shishun Fu, Guihua Jiang Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, Guangzhou, People’s Republic of China Abstract: The investigation of the mechanism of insomnia could provide the basis for improved understanding and treatment of insomnia. The aim of this study is to investigate the abnormal functional connectivity throughout the entire brain of insomnia patients, and analyze the global distribution of these abnormalities. Whole brains of 50 patients with insomnia and 40 healthy controls were divided into 116 regions and abnormal connectivities were identified by comparing the Pearson’s correlation coefficients of each pair using general linear model analyses with covariates of age, sex, and duration of education. In patients with insomnia, regions that relate to wakefulness, emotion, worry/rumination, saliency/attention, and sensory-motor showed increased positive connectivity with each other; however, regions that often restrain each other, such as regions in salience network with regions in default mode network, showed decreased positive connectivity. Correlation analysis indicated that some increased positive functional connectivity was associated with the Self-Rating Depression Scale, Insomnia Severity Index, and Pittsburgh Sleep Quality Index scores. According to our findings, increased and decreased positive connectivities suggest function strengthening and function disinhibition, respectively, which offers a parsimonious explanation for the hyperarousal hypothesis in the level of the whole-brain functional connectivity in patients with insomnia. Keywords: primary insomnia, hyperarousal hypothesis, resting-state functional magnetic resonance imaging, functional connectivity, whole brainLi CDong MYin YHua KFu SJiang GDove Medical Pressarticleprimary insomniahyperarousal hypothesisresting-state fMRIfunctional connectivitywhole-brain.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 427-435 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary insomnia hyperarousal hypothesis resting-state fMRI functional connectivity whole-brain. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	primary insomnia hyperarousal hypothesis resting-state fMRI functional connectivity whole-brain. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li C Dong M Yin Y Hua K Fu S Jiang G Abnormal whole-brain functional connectivity in patients with primary insomnia
description	Chao Li, Mengshi Dong, Yi Yin, Kelei Hua, Shishun Fu, Guihua Jiang Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, Guangzhou, People’s Republic of China Abstract: The investigation of the mechanism of insomnia could provide the basis for improved understanding and treatment of insomnia. The aim of this study is to investigate the abnormal functional connectivity throughout the entire brain of insomnia patients, and analyze the global distribution of these abnormalities. Whole brains of 50 patients with insomnia and 40 healthy controls were divided into 116 regions and abnormal connectivities were identified by comparing the Pearson’s correlation coefficients of each pair using general linear model analyses with covariates of age, sex, and duration of education. In patients with insomnia, regions that relate to wakefulness, emotion, worry/rumination, saliency/attention, and sensory-motor showed increased positive connectivity with each other; however, regions that often restrain each other, such as regions in salience network with regions in default mode network, showed decreased positive connectivity. Correlation analysis indicated that some increased positive functional connectivity was associated with the Self-Rating Depression Scale, Insomnia Severity Index, and Pittsburgh Sleep Quality Index scores. According to our findings, increased and decreased positive connectivities suggest function strengthening and function disinhibition, respectively, which offers a parsimonious explanation for the hyperarousal hypothesis in the level of the whole-brain functional connectivity in patients with insomnia. Keywords: primary insomnia, hyperarousal hypothesis, resting-state functional magnetic resonance imaging, functional connectivity, whole brain
format	article
author	Li C Dong M Yin Y Hua K Fu S Jiang G
author_facet	Li C Dong M Yin Y Hua K Fu S Jiang G
author_sort	Li C
title	Abnormal whole-brain functional connectivity in patients with primary insomnia
title_short	Abnormal whole-brain functional connectivity in patients with primary insomnia
title_full	Abnormal whole-brain functional connectivity in patients with primary insomnia
title_fullStr	Abnormal whole-brain functional connectivity in patients with primary insomnia
title_full_unstemmed	Abnormal whole-brain functional connectivity in patients with primary insomnia
title_sort	abnormal whole-brain functional connectivity in patients with primary insomnia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/43e257a72420487e8ced0d6590dcf8d5
work_keys_str_mv	AT lic abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia AT dongm abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia AT yiny abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia AT huak abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia AT fus abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia AT jiangg abnormalwholebrainfunctionalconnectivityinpatientswithprimaryinsomnia
_version_	1718399809664057344

Abnormal whole-brain functional connectivity in patients with primary insomnia

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