Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study

Abstract We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single an...

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Autores principales:	A. Scharmga, K. K. Keller, M. Peters, A. van Tubergen, J. P. van den Bergh, B. van Rietbergen, R. Weijers, D. Loeffen, E. M. Hauge, P. Geusens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43e279d9054e4e26ac692344cc08148d
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spelling	oai:doaj.org-article:43e279d9054e4e26ac692344cc08148d2021-12-02T11:52:17ZVascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study10.1038/s41598-017-09363-22045-2322https://doaj.org/article/43e279d9054e4e26ac692344cc08148d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09363-2https://doaj.org/toc/2045-2322Abstract We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multiplane HR-pQCT images. Four 3-mm thick portions in three anatomic metacarpophalangeal joint specimens were selected for histologic sectioning. First, VCs identified with HR-pQCT were examined for confirmation on histology. Second and independently, VCs identified by histology were matched to single and multiplane HR-pQCT images to assess for presence of cortical interruptions. Only one out of five cortical interruptions suggestive for VC on HR-pQCT could be confirmed on histology. In contrast, 52 VCs were identified by histology of which 39 (75%) could be classified as cortical interruption or periosteal excavation on matched single HR-pQCT slices. On multiplane HR-pQCT images, 11 (21%) showed a cortical interruption in at least two consecutive slices in two planes, 36 (69%) in at least one slice in two planes and five (10%) showed no cortical interruption. Substantially more VCs were present in histology sections than initially suggested by HR-pQCT. The small size and heterogeneous presentation, limit the identification as VC on HR-pQCT.A. ScharmgaK. K. KellerM. PetersA. van TubergenJ. P. van den BerghB. van RietbergenR. WeijersD. LoeffenE. M. HaugeP. GeusensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Scharmga K. K. Keller M. Peters A. van Tubergen J. P. van den Bergh B. van Rietbergen R. Weijers D. Loeffen E. M. Hauge P. Geusens Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
description	Abstract We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multiplane HR-pQCT images. Four 3-mm thick portions in three anatomic metacarpophalangeal joint specimens were selected for histologic sectioning. First, VCs identified with HR-pQCT were examined for confirmation on histology. Second and independently, VCs identified by histology were matched to single and multiplane HR-pQCT images to assess for presence of cortical interruptions. Only one out of five cortical interruptions suggestive for VC on HR-pQCT could be confirmed on histology. In contrast, 52 VCs were identified by histology of which 39 (75%) could be classified as cortical interruption or periosteal excavation on matched single HR-pQCT slices. On multiplane HR-pQCT images, 11 (21%) showed a cortical interruption in at least two consecutive slices in two planes, 36 (69%) in at least one slice in two planes and five (10%) showed no cortical interruption. Substantially more VCs were present in histology sections than initially suggested by HR-pQCT. The small size and heterogeneous presentation, limit the identification as VC on HR-pQCT.
format	article
author	A. Scharmga K. K. Keller M. Peters A. van Tubergen J. P. van den Bergh B. van Rietbergen R. Weijers D. Loeffen E. M. Hauge P. Geusens
author_facet	A. Scharmga K. K. Keller M. Peters A. van Tubergen J. P. van den Bergh B. van Rietbergen R. Weijers D. Loeffen E. M. Hauge P. Geusens
author_sort	A. Scharmga
title	Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_short	Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_full	Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_fullStr	Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_full_unstemmed	Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_sort	vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/43e279d9054e4e26ac692344cc08148d
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Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study

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