Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat

BACKGROUND AND OBJECTIVE: Most of these contaminants, by increased production of free radicals of oxygen, cause nephrotoxicity in human and experimental animals. Anti-oxidant structures existing in the medicinal plants are suitable candidates for protection against poisoning by these substances. In...

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Autores principales:	M Zaheri, S Ebrahimi Vosta Kalai, J Cheraghi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	scrophularia striata nephrotoxicity mercury cadmium Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/43e28e5fb87641a6b12dfd1365a5b7b7
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spelling	oai:doaj.org-article:43e28e5fb87641a6b12dfd1365a5b7b72021-11-10T08:56:42ZProtective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat1561-41072251-7170https://doaj.org/article/43e28e5fb87641a6b12dfd1365a5b7b72011-07-01T00:00:00Zhttp://jbums.org/article-1-3842-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Most of these contaminants, by increased production of free radicals of oxygen, cause nephrotoxicity in human and experimental animals. Anti-oxidant structures existing in the medicinal plants are suitable candidates for protection against poisoning by these substances. In the present research, for the first time, the effect of the alcoholic juice of the aerial sections of scrophularia striata (Teshnehdaru) on nephrotoxicity caused by cadmium and mercury is investigated.METHODS: Forty two male Wistar rats (200-250 g) were randomly divided into 6 groups (n=7) to receive a daily corresponding dose of cadmium chloride (3mg/kg, i.p., group Cd), mercuric chloride (1.5mg/kg, i.p., group Hg), extract of Scrophularia striata (400 mg/kg, i.p., group Ss), combination extract and cadmium chloride (CS), combination extract and mercury chloride (HS) and normal saline as control (CT). At the end of the 8 day blood samples were collected and nephrotoxicity was evaluated by measuring serum urea, serum creatinine, blood urea nitrogen (BUN) and uric acid concentration. FINDINGS: Administration of hydroalcoholic extract of Scrophularia striata induced a significant decrease urea and uric acid compared with control group. Cd- induced increases in urea, creatinine, BUN and uric acid were significantly reduced by treatment with extract. In compared with control group in Hg group uric acid and creatinine increased but urea and BUN decreased. Treatment with extract improved nephrotoxicity. CONCLUSION: The results showed that scrophularia striata may have a protective effect against heavy metal induced nephrotoxicity.M ZaheriS Ebrahimi Vosta KalaiJ CheraghiBabol University of Medical Sciencesarticlescrophularia striatanephrotoxicitymercurycadmiumMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 48-53 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	scrophularia striata nephrotoxicity mercury cadmium Medicine R Medicine (General) R5-920
spellingShingle	scrophularia striata nephrotoxicity mercury cadmium Medicine R Medicine (General) R5-920 M Zaheri S Ebrahimi Vosta Kalai J Cheraghi Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
description	BACKGROUND AND OBJECTIVE: Most of these contaminants, by increased production of free radicals of oxygen, cause nephrotoxicity in human and experimental animals. Anti-oxidant structures existing in the medicinal plants are suitable candidates for protection against poisoning by these substances. In the present research, for the first time, the effect of the alcoholic juice of the aerial sections of scrophularia striata (Teshnehdaru) on nephrotoxicity caused by cadmium and mercury is investigated.METHODS: Forty two male Wistar rats (200-250 g) were randomly divided into 6 groups (n=7) to receive a daily corresponding dose of cadmium chloride (3mg/kg, i.p., group Cd), mercuric chloride (1.5mg/kg, i.p., group Hg), extract of Scrophularia striata (400 mg/kg, i.p., group Ss), combination extract and cadmium chloride (CS), combination extract and mercury chloride (HS) and normal saline as control (CT). At the end of the 8 day blood samples were collected and nephrotoxicity was evaluated by measuring serum urea, serum creatinine, blood urea nitrogen (BUN) and uric acid concentration. FINDINGS: Administration of hydroalcoholic extract of Scrophularia striata induced a significant decrease urea and uric acid compared with control group. Cd- induced increases in urea, creatinine, BUN and uric acid were significantly reduced by treatment with extract. In compared with control group in Hg group uric acid and creatinine increased but urea and BUN decreased. Treatment with extract improved nephrotoxicity. CONCLUSION: The results showed that scrophularia striata may have a protective effect against heavy metal induced nephrotoxicity.
format	article
author	M Zaheri S Ebrahimi Vosta Kalai J Cheraghi
author_facet	M Zaheri S Ebrahimi Vosta Kalai J Cheraghi
author_sort	M Zaheri
title	Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
title_short	Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
title_full	Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
title_fullStr	Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
title_full_unstemmed	Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
title_sort	protective effect of aerial parts extract of scrophularia striata on cadmium and mercury-induced nephrotoxicity in rat
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/43e28e5fb87641a6b12dfd1365a5b7b7
work_keys_str_mv	AT mzaheri protectiveeffectofaerialpartsextractofscrophulariastriataoncadmiumandmercuryinducednephrotoxicityinrat AT sebrahimivostakalai protectiveeffectofaerialpartsextractofscrophulariastriataoncadmiumandmercuryinducednephrotoxicityinrat AT jcheraghi protectiveeffectofaerialpartsextractofscrophulariastriataoncadmiumandmercuryinducednephrotoxicityinrat
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Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat

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