Anatomical and functional brain abnormalities in unmedicated major depressive disorder

Xiao Yang,1,2,* Xiaojuan Ma,3,* Mingli Li,1,2 Ye Liu,1 Jian Zhang,1 Bin Huang,4 Liansheng Zhao,1,2 Wei Deng,1,2 Tao Li,1,2 Xiaohong Ma1,2 1Psychiatric Laboratory and Department of Psychiatry, 2National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 3Chengdu First People&...

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Autores principales:	Yang X, Ma X, Li M, Liu Y, Zhang J, Huang B, Zhao L, Deng W, Li T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/43e3eaaa58e94556aeb3c07f031f1f22
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spelling	oai:doaj.org-article:43e3eaaa58e94556aeb3c07f031f1f222021-12-02T07:27:45ZAnatomical and functional brain abnormalities in unmedicated major depressive disorder1178-2021https://doaj.org/article/43e3eaaa58e94556aeb3c07f031f1f222015-09-01T00:00:00Zhttps://www.dovepress.com/anatomical-and-functional-brain-abnormalities-in-unmedicated-major-dep-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiao Yang,1,2,* Xiaojuan Ma,3,* Mingli Li,1,2 Ye Liu,1 Jian Zhang,1 Bin Huang,4 Liansheng Zhao,1,2 Wei Deng,1,2 Tao Li,1,2 Xiaohong Ma1,2 1Psychiatric Laboratory and Department of Psychiatry, 2National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 3Chengdu First People’s Hospital, Chengdu, 4Dong Feng Mao Jian Hospital, Shiyan, People’s Republic of China *These authors contributed equally to this work Background: Using magnetic resonance imaging (MRI) and resting-state functional magnetic resonance imaging (rsfMRI) to explore the mechanism of brain structure and function in unmedicated patients with major depressive disorder (MDD). Patients and methods: Fifty patients with MDD and 50 matched healthy control participants free of psychotropic medication underwent high-resolution structural and rsfMRI scanning. Optimized diffeomorphic anatomical registration through exponentiated lie algebra and the Data Processing Assistant for rsfMRI were used to find potential differences in gray-matter volume (GMV) and regional homogeneity (ReHo) between the two groups. A Pearson correlation model was used to analyze associations of morphometric and functional changes with clinical symptoms. Results: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected). In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls. There was no overlap between anatomical and functional changes. Linear correlation suggested no significant correlation between mean GMV values within regions with anatomical abnormality and ReHo values in regions with functional abnormality in the patient group. These changes were not significantly correlated with symptom severity. Conclusion: Our study suggests a dissociation pattern of brain regions with anatomical and functional alterations in unmedicated patients with MDD, especially with regard to GMV and ReHo. Keywords: major depressive disorder, functional magnetic resonance imaging, gray-matter volume, regional homogeneityYang XMa XLi MLiu YZhang JHuang BZhao LDeng WLi TMa XDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2415-2423 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang X Ma X Li M Liu Y Zhang J Huang B Zhao L Deng W Li T Ma X Anatomical and functional brain abnormalities in unmedicated major depressive disorder
description	Xiao Yang,1,2,* Xiaojuan Ma,3,* Mingli Li,1,2 Ye Liu,1 Jian Zhang,1 Bin Huang,4 Liansheng Zhao,1,2 Wei Deng,1,2 Tao Li,1,2 Xiaohong Ma1,2 1Psychiatric Laboratory and Department of Psychiatry, 2National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 3Chengdu First People’s Hospital, Chengdu, 4Dong Feng Mao Jian Hospital, Shiyan, People’s Republic of China *These authors contributed equally to this work Background: Using magnetic resonance imaging (MRI) and resting-state functional magnetic resonance imaging (rsfMRI) to explore the mechanism of brain structure and function in unmedicated patients with major depressive disorder (MDD). Patients and methods: Fifty patients with MDD and 50 matched healthy control participants free of psychotropic medication underwent high-resolution structural and rsfMRI scanning. Optimized diffeomorphic anatomical registration through exponentiated lie algebra and the Data Processing Assistant for rsfMRI were used to find potential differences in gray-matter volume (GMV) and regional homogeneity (ReHo) between the two groups. A Pearson correlation model was used to analyze associations of morphometric and functional changes with clinical symptoms. Results: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected). In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls. There was no overlap between anatomical and functional changes. Linear correlation suggested no significant correlation between mean GMV values within regions with anatomical abnormality and ReHo values in regions with functional abnormality in the patient group. These changes were not significantly correlated with symptom severity. Conclusion: Our study suggests a dissociation pattern of brain regions with anatomical and functional alterations in unmedicated patients with MDD, especially with regard to GMV and ReHo. Keywords: major depressive disorder, functional magnetic resonance imaging, gray-matter volume, regional homogeneity
format	article
author	Yang X Ma X Li M Liu Y Zhang J Huang B Zhao L Deng W Li T Ma X
author_facet	Yang X Ma X Li M Liu Y Zhang J Huang B Zhao L Deng W Li T Ma X
author_sort	Yang X
title	Anatomical and functional brain abnormalities in unmedicated major depressive disorder
title_short	Anatomical and functional brain abnormalities in unmedicated major depressive disorder
title_full	Anatomical and functional brain abnormalities in unmedicated major depressive disorder
title_fullStr	Anatomical and functional brain abnormalities in unmedicated major depressive disorder
title_full_unstemmed	Anatomical and functional brain abnormalities in unmedicated major depressive disorder
title_sort	anatomical and functional brain abnormalities in unmedicated major depressive disorder
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/43e3eaaa58e94556aeb3c07f031f1f22
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Anatomical and functional brain abnormalities in unmedicated major depressive disorder

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