The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.

To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in...

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Autores principales:	Antita Adriaens, Kathelijne Peremans, Tim Waelbers, Eva Vandermeulen, Siska Croubels, Luc Duchateau, André Dobbeleir, Kurt Audenaert, Jos Eersels, Simon Vermeire, Bart De Spiegeleer, Ingeborgh Polis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43e47b5f015846fdb7bbc08b44fe7b9e
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spelling	oai:doaj.org-article:43e47b5f015846fdb7bbc08b44fe7b9e2021-11-25T05:57:32ZThe effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.1932-620310.1371/journal.pone.0109680https://doaj.org/article/43e47b5f015846fdb7bbc08b44fe7b9e2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109680https://doaj.org/toc/1932-6203To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.Antita AdriaensKathelijne PeremansTim WaelbersEva VandermeulenSiska CroubelsLuc DuchateauAndré DobbeleirKurt AudenaertJos EerselsSimon VermeireBart De SpiegeleerIngeborgh PolisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109680 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antita Adriaens Kathelijne Peremans Tim Waelbers Eva Vandermeulen Siska Croubels Luc Duchateau André Dobbeleir Kurt Audenaert Jos Eersels Simon Vermeire Bart De Spiegeleer Ingeborgh Polis The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
description	To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.
format	article
author	Antita Adriaens Kathelijne Peremans Tim Waelbers Eva Vandermeulen Siska Croubels Luc Duchateau André Dobbeleir Kurt Audenaert Jos Eersels Simon Vermeire Bart De Spiegeleer Ingeborgh Polis
author_facet	Antita Adriaens Kathelijne Peremans Tim Waelbers Eva Vandermeulen Siska Croubels Luc Duchateau André Dobbeleir Kurt Audenaert Jos Eersels Simon Vermeire Bart De Spiegeleer Ingeborgh Polis
author_sort	Antita Adriaens
title	The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
title_short	The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
title_full	The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
title_fullStr	The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
title_full_unstemmed	The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
title_sort	effect of morphine on regional cerebral blood flow measured by 99mtc-ecd spect in dogs.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/43e47b5f015846fdb7bbc08b44fe7b9e
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The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.

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