Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations

The gastric H+,K+-ATPase is a proton pump that creates the acidic environment of the stomach lumen, maintaining high proton gradient across the gastric mucosa cell membrane. Here, structural analysis of rationally designed H+,K+-ATPase mutants provides insight into this and other P-type ATPases cati...

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Autores principales:	Kazuhiro Abe, Kenta Yamamoto, Katsumasa Irie, Tomohiro Nishizawa, Atsunori Oshima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43e7c12472084d38b471a2586ea30d0a
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spelling	oai:doaj.org-article:43e7c12472084d38b471a2586ea30d0a2021-12-02T18:51:09ZGastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations10.1038/s41467-021-26024-12041-1723https://doaj.org/article/43e7c12472084d38b471a2586ea30d0a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26024-1https://doaj.org/toc/2041-1723The gastric H+,K+-ATPase is a proton pump that creates the acidic environment of the stomach lumen, maintaining high proton gradient across the gastric mucosa cell membrane. Here, structural analysis of rationally designed H+,K+-ATPase mutants provides insight into this and other P-type ATPases cation binding stoichiometry and mechanisms.Kazuhiro AbeKenta YamamotoKatsumasa IrieTomohiro NishizawaAtsunori OshimaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuhiro Abe Kenta Yamamoto Katsumasa Irie Tomohiro Nishizawa Atsunori Oshima Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
description	The gastric H+,K+-ATPase is a proton pump that creates the acidic environment of the stomach lumen, maintaining high proton gradient across the gastric mucosa cell membrane. Here, structural analysis of rationally designed H+,K+-ATPase mutants provides insight into this and other P-type ATPases cation binding stoichiometry and mechanisms.
format	article
author	Kazuhiro Abe Kenta Yamamoto Katsumasa Irie Tomohiro Nishizawa Atsunori Oshima
author_facet	Kazuhiro Abe Kenta Yamamoto Katsumasa Irie Tomohiro Nishizawa Atsunori Oshima
author_sort	Kazuhiro Abe
title	Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
title_short	Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
title_full	Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
title_fullStr	Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
title_full_unstemmed	Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations
title_sort	gastric proton pump with two occluded k+ engineered with sodium pump-mimetic mutations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43e7c12472084d38b471a2586ea30d0a
work_keys_str_mv	AT kazuhiroabe gastricprotonpumpwithtwooccludedkengineeredwithsodiumpumpmimeticmutations AT kentayamamoto gastricprotonpumpwithtwooccludedkengineeredwithsodiumpumpmimeticmutations AT katsumasairie gastricprotonpumpwithtwooccludedkengineeredwithsodiumpumpmimeticmutations AT tomohironishizawa gastricprotonpumpwithtwooccludedkengineeredwithsodiumpumpmimeticmutations AT atsunorioshima gastricprotonpumpwithtwooccludedkengineeredwithsodiumpumpmimeticmutations
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Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations

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