A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray crystal structure of human IKK2 (hIKK2) in its cata...

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Autores principales: Smarajit Polley, De-Bin Huang, Arthur V Hauenstein, Amanda J Fusco, Xiangyang Zhong, Don Vu, Bärbel Schröfelbauer, Youngchang Kim, Alexander Hoffmann, Inder M Verma, Gourisankar Ghosh, Tom Huxford
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/43e7e959d3ba4586a7f0c6da67fd6cc8
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