MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA

Abstract. The aim of this work was detection of class 1 integrons and their contribution to the antimicrobial resistance phenotypes in strains of subspecies enterica serotype Enteritidis. S. Enteritidis strains (n = 29) were isolated from patients with salmonellosis at “Nork” Clinical Hospital of...

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Autores principales:	A. M. Sedrakyan, K. A. Arakelova, M. K. Zakaryan, A. I. Hovhanisyan, A. V. Asoyan, Z. U. Gevorkyan, A. A. Mnatsakanyan, Z. A. Ktsoyan, A. S. Boyajyan, R. Aminov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	salmonella enterica serotype enteritidis multidrug-resistance class 1 integrons Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/43e8cbe316e84042933078ce41a69e52
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spelling	oai:doaj.org-article:43e8cbe316e84042933078ce41a69e522021-11-22T07:09:46ZMULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA2220-76192313-739810.15789/2220-7619-2013-4-355-358https://doaj.org/article/43e8cbe316e84042933078ce41a69e522014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/145https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The aim of this work was detection of class 1 integrons and their contribution to the antimicrobial resistance phenotypes in strains of subspecies enterica serotype Enteritidis. S. Enteritidis strains (n = 29) were isolated from patients with salmonellosis at “Nork” Clinical Hospital of Infectious Diseases, Yerevan, Republic of Armenia. High prevalence of multi-drug resistance (MDR) phenotypes was revealed and isolates with MDR phenotypes which are rare in the S. Enteritidis serotype were observed. Class 1 integrons were detected in 27,6% of isolates, with the prevalence of a variable region of 1000 bp. Occurrence of the MDR phenotype was more frequent in integron-positive isolates compared to integron-negative isolates of S. Enteritidis. Further studies are necessary to reveal the genetic background of MDR phenotypes and to estimate the genetic kinship among the isolates. Our results suggest a rapid and large-scale penetration of antibiotic resistance genes into populations of S. Enteritidis, which complicates infection control. More rigorous regulations should be imposed on antibiotic use, together with a vigilant epidemiological surveillance, to prevent the emergence and spread of MDR S. Enteritidis.A. M. SedrakyanK. A. ArakelovaM. K. ZakaryanA. I. HovhanisyanA. V. AsoyanZ. U. GevorkyanA. A. MnatsakanyanZ. A. KtsoyanA. S. BoyajyanR. AminovSankt-Peterburg : NIIÈM imeni Pasteraarticlesalmonella enterica serotype enteritidismultidrug-resistanceclass 1 integronsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 4, Pp 355-358 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	salmonella enterica serotype enteritidis multidrug-resistance class 1 integrons Infectious and parasitic diseases RC109-216
spellingShingle	salmonella enterica serotype enteritidis multidrug-resistance class 1 integrons Infectious and parasitic diseases RC109-216 A. M. Sedrakyan K. A. Arakelova M. K. Zakaryan A. I. Hovhanisyan A. V. Asoyan Z. U. Gevorkyan A. A. Mnatsakanyan Z. A. Ktsoyan A. S. Boyajyan R. Aminov MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
description	Abstract. The aim of this work was detection of class 1 integrons and their contribution to the antimicrobial resistance phenotypes in strains of subspecies enterica serotype Enteritidis. S. Enteritidis strains (n = 29) were isolated from patients with salmonellosis at “Nork” Clinical Hospital of Infectious Diseases, Yerevan, Republic of Armenia. High prevalence of multi-drug resistance (MDR) phenotypes was revealed and isolates with MDR phenotypes which are rare in the S. Enteritidis serotype were observed. Class 1 integrons were detected in 27,6% of isolates, with the prevalence of a variable region of 1000 bp. Occurrence of the MDR phenotype was more frequent in integron-positive isolates compared to integron-negative isolates of S. Enteritidis. Further studies are necessary to reveal the genetic background of MDR phenotypes and to estimate the genetic kinship among the isolates. Our results suggest a rapid and large-scale penetration of antibiotic resistance genes into populations of S. Enteritidis, which complicates infection control. More rigorous regulations should be imposed on antibiotic use, together with a vigilant epidemiological surveillance, to prevent the emergence and spread of MDR S. Enteritidis.
format	article
author	A. M. Sedrakyan K. A. Arakelova M. K. Zakaryan A. I. Hovhanisyan A. V. Asoyan Z. U. Gevorkyan A. A. Mnatsakanyan Z. A. Ktsoyan A. S. Boyajyan R. Aminov
author_facet	A. M. Sedrakyan K. A. Arakelova M. K. Zakaryan A. I. Hovhanisyan A. V. Asoyan Z. U. Gevorkyan A. A. Mnatsakanyan Z. A. Ktsoyan A. S. Boyajyan R. Aminov
author_sort	A. M. Sedrakyan
title	MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
title_short	MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
title_full	MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
title_fullStr	MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
title_full_unstemmed	MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA
title_sort	multidrug-resistance and presence of class 1 integrons in clinical isolates of salmonella enterica serotype enteritidis, circulating in armenia
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/43e8cbe316e84042933078ce41a69e52
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MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA

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