FOXO3a and Its Regulators in Prostate Cancer

Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle regulation, and DNA damage. As a transcription factor, FOXO3a is involved in the response to cellular stress, UV radiati...

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Autores principales:	Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer foxo3a Akt proliferation apoptosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/43e8d3665d1048a7bf76a21f3ec18423
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id	oai:doaj.org-article:43e8d3665d1048a7bf76a21f3ec18423
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spelling	oai:doaj.org-article:43e8d3665d1048a7bf76a21f3ec184232021-11-25T17:57:30ZFOXO3a and Its Regulators in Prostate Cancer10.3390/ijms2222125301422-00671661-6596https://doaj.org/article/43e8d3665d1048a7bf76a21f3ec184232021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12530https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle regulation, and DNA damage. As a transcription factor, FOXO3a is involved in the response to cellular stress, UV radiation, or oxidative stress. Its regulation is based on the modification of proteins as well as regulation by other proteins, e.g., growth factors. FOXO3a is commonly deregulated in cancer cells, and its inactivation is associated with initiation and progression of tumorigenesis, suggesting its role as a tumor suppressor; however, its role is still disputed and seems to be dependent on upstream signaling. Nevertheless, FOXO3a serves as an interesting potential target in therapies as it is regulated during treatment with very common anti-cancer drugs such as paclitaxel, cisplatin, docetaxel, and doxorubicin. This review aims to update the reported role of FOXO3a in prostate cancer (PCa), with a focus on its regulators that might serve as potential therapeutic agents in PCa therapy.Dominika Ewa Habrowska-GórczyńskaMarta Justyna KoziełKarolina KowalskaAgnieszka Wanda Piastowska-CiesielskaMDPI AGarticleprostate cancerfoxo3aAktproliferationapoptosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12530, p 12530 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer foxo3a Akt proliferation apoptosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	prostate cancer foxo3a Akt proliferation apoptosis Biology (General) QH301-705.5 Chemistry QD1-999 Dominika Ewa Habrowska-Górczyńska Marta Justyna Kozieł Karolina Kowalska Agnieszka Wanda Piastowska-Ciesielska FOXO3a and Its Regulators in Prostate Cancer
description	Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle regulation, and DNA damage. As a transcription factor, FOXO3a is involved in the response to cellular stress, UV radiation, or oxidative stress. Its regulation is based on the modification of proteins as well as regulation by other proteins, e.g., growth factors. FOXO3a is commonly deregulated in cancer cells, and its inactivation is associated with initiation and progression of tumorigenesis, suggesting its role as a tumor suppressor; however, its role is still disputed and seems to be dependent on upstream signaling. Nevertheless, FOXO3a serves as an interesting potential target in therapies as it is regulated during treatment with very common anti-cancer drugs such as paclitaxel, cisplatin, docetaxel, and doxorubicin. This review aims to update the reported role of FOXO3a in prostate cancer (PCa), with a focus on its regulators that might serve as potential therapeutic agents in PCa therapy.
format	article
author	Dominika Ewa Habrowska-Górczyńska Marta Justyna Kozieł Karolina Kowalska Agnieszka Wanda Piastowska-Ciesielska
author_facet	Dominika Ewa Habrowska-Górczyńska Marta Justyna Kozieł Karolina Kowalska Agnieszka Wanda Piastowska-Ciesielska
author_sort	Dominika Ewa Habrowska-Górczyńska
title	FOXO3a and Its Regulators in Prostate Cancer
title_short	FOXO3a and Its Regulators in Prostate Cancer
title_full	FOXO3a and Its Regulators in Prostate Cancer
title_fullStr	FOXO3a and Its Regulators in Prostate Cancer
title_full_unstemmed	FOXO3a and Its Regulators in Prostate Cancer
title_sort	foxo3a and its regulators in prostate cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/43e8d3665d1048a7bf76a21f3ec18423
work_keys_str_mv	AT dominikaewahabrowskagorczynska foxo3aanditsregulatorsinprostatecancer AT martajustynakozieł foxo3aanditsregulatorsinprostatecancer AT karolinakowalska foxo3aanditsregulatorsinprostatecancer AT agnieszkawandapiastowskaciesielska foxo3aanditsregulatorsinprostatecancer
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FOXO3a and Its Regulators in Prostate Cancer

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