MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord

MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord

In the spinal cord, someHox genes are transcribed in progenitors while their proteins are only detected in differentiating postmitotic motor neurons. Here, the authors show that miRNAs (specifically mir-27) regulate post-transcriptional Hoxa5 expression in motor neurons.

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Autores principales: Chung-Jung Li, Tian Hong, Ying-Tsen Tung, Ya-Ping Yen, Ho-Chiang Hsu, Ya-Lin Lu, Mien Chang, Qing Nie, Jun-An Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/43eb2d8348ea4cf8b5060a8a551fe66c
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