Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Abstract Although several studies have confirmed the clinical significance of the systemic inflammation markers in hepatocellular carcinoma (HCC), evaluating the clinical significance of each blood cell remains to be conducted. We aimed to evaluate the clinical importance of absolute counts of blood...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeong Il Yu, Hee Chul Park, Gyu Sang Yoo, Changhoon Choi, Moon Seok Choi, Heerim Nam, Sun-Young Baek, Minsu Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43eee005d4524c1ea00bd804d555ea6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43eee005d4524c1ea00bd804d555ea6e
record_format	dspace
spelling	oai:doaj.org-article:43eee005d4524c1ea00bd804d555ea6e2021-12-02T13:57:59ZClinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma10.1038/s41598-021-82177-52045-2322https://doaj.org/article/43eee005d4524c1ea00bd804d555ea6e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82177-5https://doaj.org/toc/2045-2322Abstract Although several studies have confirmed the clinical significance of the systemic inflammation markers in hepatocellular carcinoma (HCC), evaluating the clinical significance of each blood cell remains to be conducted. We aimed to evaluate the clinical importance of absolute counts of blood cells in the overall survival (OS) of patients with newly diagnosed HCC. We recruited patient cohorts from the prospective registry of newly diagnosed and previously untreated HCC at Samsung Medical Center, which included a training set of 6619 patients (2005–2013) and a validation set of 2084 patients (2014–2016). More than three-quarters of all patients had hepatitis B virus (HBV)-related HCC in both training and validation sets. The optimal cutoff values of the absolute counts of neutrophils, lymphocytes, monocytes, and platelets were 3917, 488, 1379, and 22,100, respectively, which correlated significantly with OS. The absolute blood cell counts categorized by each optimal cutoff value significantly correlated with liver function status determined by Child–Pugh class/albumin-bilirubin (ALBI) grade and the HCC burden determined by several staging systems/portal vein tumor thrombosis. Although the prognostic model based on these blood cells (ABC model) showed a lower prognostic ability than the Japan Integrated Staging or ALBI-T staging systems, it provided significant discrimination of survival in the subgroups of ALBI-T and showed the highest prognostic ability in the present study in the training and validation sets. Absolute counts of blood cells are independently associated with OS, though it is also significantly associated with liver function and tumor burden in newly diagnosed HCC.Jeong Il YuHee Chul ParkGyu Sang YooChanghoon ChoiMoon Seok ChoiHeerim NamSun-Young BaekMinsu ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong Il Yu Hee Chul Park Gyu Sang Yoo Changhoon Choi Moon Seok Choi Heerim Nam Sun-Young Baek Minsu Park Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
description	Abstract Although several studies have confirmed the clinical significance of the systemic inflammation markers in hepatocellular carcinoma (HCC), evaluating the clinical significance of each blood cell remains to be conducted. We aimed to evaluate the clinical importance of absolute counts of blood cells in the overall survival (OS) of patients with newly diagnosed HCC. We recruited patient cohorts from the prospective registry of newly diagnosed and previously untreated HCC at Samsung Medical Center, which included a training set of 6619 patients (2005–2013) and a validation set of 2084 patients (2014–2016). More than three-quarters of all patients had hepatitis B virus (HBV)-related HCC in both training and validation sets. The optimal cutoff values of the absolute counts of neutrophils, lymphocytes, monocytes, and platelets were 3917, 488, 1379, and 22,100, respectively, which correlated significantly with OS. The absolute blood cell counts categorized by each optimal cutoff value significantly correlated with liver function status determined by Child–Pugh class/albumin-bilirubin (ALBI) grade and the HCC burden determined by several staging systems/portal vein tumor thrombosis. Although the prognostic model based on these blood cells (ABC model) showed a lower prognostic ability than the Japan Integrated Staging or ALBI-T staging systems, it provided significant discrimination of survival in the subgroups of ALBI-T and showed the highest prognostic ability in the present study in the training and validation sets. Absolute counts of blood cells are independently associated with OS, though it is also significantly associated with liver function and tumor burden in newly diagnosed HCC.
format	article
author	Jeong Il Yu Hee Chul Park Gyu Sang Yoo Changhoon Choi Moon Seok Choi Heerim Nam Sun-Young Baek Minsu Park
author_facet	Jeong Il Yu Hee Chul Park Gyu Sang Yoo Changhoon Choi Moon Seok Choi Heerim Nam Sun-Young Baek Minsu Park
author_sort	Jeong Il Yu
title	Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
title_short	Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
title_full	Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
title_fullStr	Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
title_full_unstemmed	Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
title_sort	clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43eee005d4524c1ea00bd804d555ea6e
work_keys_str_mv	AT jeongilyu clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT heechulpark clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT gyusangyoo clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT changhoonchoi clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT moonseokchoi clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT heerimnam clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT sunyoungbaek clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma AT minsupark clinicalimportanceoftheabsolutecountofneutrophilslymphocytesmonocytesandplateletsinnewlydiagnosedhepatocellularcarcinoma
_version_	1718392255837896704

Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Ejemplares similares