Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1

ABSTRACT Human DJ-1 is a highly conserved and yet functionally enigmatic protein associated with a heritable form of Parkinson’s disease. It has been suggested to be a redox-dependent regulatory scaffold, binding to proteins to modulate their function. Here we present the X-ray crystal structure of...

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Main Authors: Matthew A. Child, Megan Garland, Ian Foe, Peter Madzelan, Moritz Treeck, Wouter A. van der Linden, Kristina Oresic Bender, Eranthie Weerapana, Mark A. Wilson, John C. Boothroyd, Michael L. Reese, Matthew Bogyo
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/43f390a0bf3541a0a635102fec2b1083
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