Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.

The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating tablet (ODT) excipients microcrystalline cellulose (MCC) and D-mannitol. This helps to elucidate the underlying physico-chemical and mechanical mec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali Al-Khattawi, Hamad Alyami, Bill Townsend, Xianghong Ma, Afzal R Mohammed
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43f815b63c724f55b2d419571b86af99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:43f815b63c724f55b2d419571b86af99
record_format	dspace
spelling	oai:doaj.org-article:43f815b63c724f55b2d419571b86af992021-11-25T06:08:26ZEvidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.1932-620310.1371/journal.pone.0101369https://doaj.org/article/43f815b63c724f55b2d419571b86af992014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25025427/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating tablet (ODT) excipients microcrystalline cellulose (MCC) and D-mannitol. This helps to elucidate the underlying physico-chemical and mechanical mechanisms responsible for powder densification and optimum product functionality. Atomic force microscopy (AFM) contact mode analysis was performed to measure nano-adhesion forces and surface energies between excipient-drug particles (6-10 different particles per each pair). Moreover, surface topography images (100 nm2-10 µm2) and roughness data were acquired from AFM tapping mode. AFM data were related to ODT macro/microscopic properties obtained from SEM, FTIR, XRD, thermal analysis using DSC and TGA, disintegration testing, Heckel and tabletability profiles. The study results showed a good association between the adhesive molecular and physical forces of paired particles and the resultant densification mechanisms responsible for mechanical strength of tablets. MCC micro roughness was 3 times that of D-mannitol which explains the high hardness of MCC ODTs due to mechanical interlocking. Hydrogen bonding between MCC particles could not be established from both AFM and FTIR solid state investigation. On the contrary, D-mannitol produced fragile ODTs due to fragmentation of surface crystallites during compression attained from its weak crystal structure. Furthermore, AFM analysis has shown the presence of extensive micro fibril structures inhabiting nano pores which further supports the use of MCC as a disintegrant. Overall, excipients (and model drugs) showed mechanistic behaviour on the nano/micro scale that could be related to the functionality of materials on the macro scale.Ali Al-KhattawiHamad AlyamiBill TownsendXianghong MaAfzal R MohammedPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e101369 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Al-Khattawi Hamad Alyami Bill Townsend Xianghong Ma Afzal R Mohammed Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
description	The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating tablet (ODT) excipients microcrystalline cellulose (MCC) and D-mannitol. This helps to elucidate the underlying physico-chemical and mechanical mechanisms responsible for powder densification and optimum product functionality. Atomic force microscopy (AFM) contact mode analysis was performed to measure nano-adhesion forces and surface energies between excipient-drug particles (6-10 different particles per each pair). Moreover, surface topography images (100 nm2-10 µm2) and roughness data were acquired from AFM tapping mode. AFM data were related to ODT macro/microscopic properties obtained from SEM, FTIR, XRD, thermal analysis using DSC and TGA, disintegration testing, Heckel and tabletability profiles. The study results showed a good association between the adhesive molecular and physical forces of paired particles and the resultant densification mechanisms responsible for mechanical strength of tablets. MCC micro roughness was 3 times that of D-mannitol which explains the high hardness of MCC ODTs due to mechanical interlocking. Hydrogen bonding between MCC particles could not be established from both AFM and FTIR solid state investigation. On the contrary, D-mannitol produced fragile ODTs due to fragmentation of surface crystallites during compression attained from its weak crystal structure. Furthermore, AFM analysis has shown the presence of extensive micro fibril structures inhabiting nano pores which further supports the use of MCC as a disintegrant. Overall, excipients (and model drugs) showed mechanistic behaviour on the nano/micro scale that could be related to the functionality of materials on the macro scale.
format	article
author	Ali Al-Khattawi Hamad Alyami Bill Townsend Xianghong Ma Afzal R Mohammed
author_facet	Ali Al-Khattawi Hamad Alyami Bill Townsend Xianghong Ma Afzal R Mohammed
author_sort	Ali Al-Khattawi
title	Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
title_short	Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
title_full	Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
title_fullStr	Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
title_full_unstemmed	Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
title_sort	evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/43f815b63c724f55b2d419571b86af99
work_keys_str_mv	AT alialkhattawi evidencebasednanoscopicandmolecularframeworkforexcipientfunctionalityincompressedorallydisintegratingtablets AT hamadalyami evidencebasednanoscopicandmolecularframeworkforexcipientfunctionalityincompressedorallydisintegratingtablets AT billtownsend evidencebasednanoscopicandmolecularframeworkforexcipientfunctionalityincompressedorallydisintegratingtablets AT xianghongma evidencebasednanoscopicandmolecularframeworkforexcipientfunctionalityincompressedorallydisintegratingtablets AT afzalrmohammed evidencebasednanoscopicandmolecularframeworkforexcipientfunctionalityincompressedorallydisintegratingtablets
_version_	1718414096562388992

Evidence-based nanoscopic and molecular framework for excipient functionality in compressed orally disintegrating tablets.

Ejemplares similares