Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts

Abstract It has been reported that geographical variation influences bone mineral density (BMD), obesity, and sarcopenia related traits in other countries. However, there is lack of similar studies in the US population. In this study, we compared data from three US study cohorts to evaluate geograph...

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Autores principales:	Yu Zhou, Kehao Wu, Hui Shen, Jigang Zhang, Hong-Wen Deng, Lan-Juan Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/43f8f79e0fea411a87e98d28ced3210d
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spelling	oai:doaj.org-article:43f8f79e0fea411a87e98d28ced3210d2021-12-02T16:08:05ZGeographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts10.1038/s41598-019-48734-92045-2322https://doaj.org/article/43f8f79e0fea411a87e98d28ced3210d2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48734-9https://doaj.org/toc/2045-2322Abstract It has been reported that geographical variation influences bone mineral density (BMD), obesity, and sarcopenia related traits in other countries. However, there is lack of similar studies in the US population. In this study, we compared data from three US study cohorts to evaluate geographical variations of BMD and body composition. BMD, fat mass and lean mass were collected from Dual-energy X-ray absorptiometry machine. ANCOVA and Chi-square tests were used to compare the differences between BMDs, obesity and sarcopenia related traits from different regional sites (Omaha, Kansas City and Baton Rouge/New Orleans). Eta-squared was used to measure the effect sizes of these differences. A total of 11,315 Caucasians from our previous three study cohorts were compared. There was no significant geographical difference in BMD for males or females under the criteria of p-values < 0.05 and effect size η2 > 0.01. There were significant geographical differences with medium effect size (p-value < 0.001, 0.01 < η2 < 0.14) for whole body fat mass percentage and index of low muscle mass. For Caucasians in the United States, there is no significant geographical effect found on BMD. The obesity and sarcopenia related traits are significantly different between the three study cohorts.Yu ZhouKehao WuHui ShenJigang ZhangHong-Wen DengLan-Juan ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Zhou Kehao Wu Hui Shen Jigang Zhang Hong-Wen Deng Lan-Juan Zhao Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
description	Abstract It has been reported that geographical variation influences bone mineral density (BMD), obesity, and sarcopenia related traits in other countries. However, there is lack of similar studies in the US population. In this study, we compared data from three US study cohorts to evaluate geographical variations of BMD and body composition. BMD, fat mass and lean mass were collected from Dual-energy X-ray absorptiometry machine. ANCOVA and Chi-square tests were used to compare the differences between BMDs, obesity and sarcopenia related traits from different regional sites (Omaha, Kansas City and Baton Rouge/New Orleans). Eta-squared was used to measure the effect sizes of these differences. A total of 11,315 Caucasians from our previous three study cohorts were compared. There was no significant geographical difference in BMD for males or females under the criteria of p-values < 0.05 and effect size η2 > 0.01. There were significant geographical differences with medium effect size (p-value < 0.001, 0.01 < η2 < 0.14) for whole body fat mass percentage and index of low muscle mass. For Caucasians in the United States, there is no significant geographical effect found on BMD. The obesity and sarcopenia related traits are significantly different between the three study cohorts.
format	article
author	Yu Zhou Kehao Wu Hui Shen Jigang Zhang Hong-Wen Deng Lan-Juan Zhao
author_facet	Yu Zhou Kehao Wu Hui Shen Jigang Zhang Hong-Wen Deng Lan-Juan Zhao
author_sort	Yu Zhou
title	Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
title_short	Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
title_full	Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
title_fullStr	Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
title_full_unstemmed	Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts
title_sort	geographical differences in osteoporosis, obesity, and sarcopenia related traits in white american cohorts
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/43f8f79e0fea411a87e98d28ced3210d
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Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts

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