SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for Pol II elongation, and SPT6 loss leads to an intes...

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Autores principales:	Jingting Li, Xiaojun Xu, Manisha Tiwari, Yifang Chen, Mackenzie Fuller, Varun Bansal, Pablo Tamayo, Soumita Das, Pradipta Ghosh, George L. Sen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43fb4cb1baf649f582d46af97ad377ec
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spelling	oai:doaj.org-article:43fb4cb1baf649f582d46af97ad377ec2021-12-02T10:44:18ZSPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation10.1038/s41467-021-21067-w2041-1723https://doaj.org/article/43fb4cb1baf649f582d46af97ad377ec2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21067-whttps://doaj.org/toc/2041-1723The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for Pol II elongation, and SPT6 loss leads to an intestine-like phenotype.Jingting LiXiaojun XuManisha TiwariYifang ChenMackenzie FullerVarun BansalPablo TamayoSoumita DasPradipta GhoshGeorge L. SenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingting Li Xiaojun Xu Manisha Tiwari Yifang Chen Mackenzie Fuller Varun Bansal Pablo Tamayo Soumita Das Pradipta Ghosh George L. Sen SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
description	The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for Pol II elongation, and SPT6 loss leads to an intestine-like phenotype.
format	article
author	Jingting Li Xiaojun Xu Manisha Tiwari Yifang Chen Mackenzie Fuller Varun Bansal Pablo Tamayo Soumita Das Pradipta Ghosh George L. Sen
author_facet	Jingting Li Xiaojun Xu Manisha Tiwari Yifang Chen Mackenzie Fuller Varun Bansal Pablo Tamayo Soumita Das Pradipta Ghosh George L. Sen
author_sort	Jingting Li
title	SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
title_short	SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
title_full	SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
title_fullStr	SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
title_full_unstemmed	SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
title_sort	spt6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/43fb4cb1baf649f582d46af97ad377ec
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SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

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