SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for Pol II elongation, and SPT6 loss leads to an intes...

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Autores principales: Jingting Li, Xiaojun Xu, Manisha Tiwari, Yifang Chen, Mackenzie Fuller, Varun Bansal, Pablo Tamayo, Soumita Das, Pradipta Ghosh, George L. Sen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/43fb4cb1baf649f582d46af97ad377ec
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