Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

Inbar Yariv,1 Anat Lipovsky,2 Aharon Gedanken,2,3 Rachel Lubart,4 Dror Fixler11Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 2Department of Chemistry, Kanbar Laboratory for Nanomaterials, Institute of Nanotechnology and Adv...

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Autores principales:	Yariv I, Lipovsky A, Gedanken A, Lubart R, Fixler D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/44001c0d7c5d427bbf65da9a431b4ec7
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spelling	oai:doaj.org-article:44001c0d7c5d427bbf65da9a431b4ec72021-12-02T02:51:10ZEnhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles1178-2013https://doaj.org/article/44001c0d7c5d427bbf65da9a431b4ec72015-05-01T00:00:00Zhttp://www.dovepress.com/enhanced-pharmacological-activity-of-vitamin-b12-and-penicillin-as-nan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Inbar Yariv,1 Anat Lipovsky,2 Aharon Gedanken,2,3 Rachel Lubart,4 Dror Fixler11Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 2Department of Chemistry, Kanbar Laboratory for Nanomaterials, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 3Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan; 4Physics and Chemistry Department, Bar-Ilan University, Ramat-Gan, IsraelAbstract: Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120–180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.Keywords: sonochemistry, antibacterial, antioxidant, Vitamin B12, Penicillin, nanomaterialsYariv ILipovsky AGedanken ALubart RFixler DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3593-3601 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yariv I Lipovsky A Gedanken A Lubart R Fixler D Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
description	Inbar Yariv,1 Anat Lipovsky,2 Aharon Gedanken,2,3 Rachel Lubart,4 Dror Fixler11Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 2Department of Chemistry, Kanbar Laboratory for Nanomaterials, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 3Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan; 4Physics and Chemistry Department, Bar-Ilan University, Ramat-Gan, IsraelAbstract: Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120–180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.Keywords: sonochemistry, antibacterial, antioxidant, Vitamin B12, Penicillin, nanomaterials
format	article
author	Yariv I Lipovsky A Gedanken A Lubart R Fixler D
author_facet	Yariv I Lipovsky A Gedanken A Lubart R Fixler D
author_sort	Yariv I
title	Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
title_short	Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
title_full	Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
title_fullStr	Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
title_full_unstemmed	Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles
title_sort	enhanced pharmacological activity of vitamin b12 and penicillin as nanoparticles
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/44001c0d7c5d427bbf65da9a431b4ec7
work_keys_str_mv	AT yarivi enhancedpharmacologicalactivityofvitaminb12andpenicillinasnanoparticles AT lipovskya enhancedpharmacologicalactivityofvitaminb12andpenicillinasnanoparticles AT gedankena enhancedpharmacologicalactivityofvitaminb12andpenicillinasnanoparticles AT lubartr enhancedpharmacologicalactivityofvitaminb12andpenicillinasnanoparticles AT fixlerd enhancedpharmacologicalactivityofvitaminb12andpenicillinasnanoparticles
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Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

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