Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.

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Detalles Bibliográficos
Autores principales: Paraskevi Krashia, Alberto Cordella, Annalisa Nobili, Livia La Barbera, Mauro Federici, Alessandro Leuti, Federica Campanelli, Giuseppina Natale, Gioia Marino, Valeria Calabrese, Francescangelo Vedele, Veronica Ghiglieri, Barbara Picconi, Giulia Di Lazzaro, Tommaso Schirinzi, Giulia Sancesario, Nicolas Casadei, Olaf Riess, Sergio Bernardini, Antonio Pisani, Paolo Calabresi, Maria Teresa Viscomi, Charles Nicholas Serhan, Valerio Chiurchiù, Marcello D’Amelio, Nicola Biagio Mercuri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/4400ee42af354c6ca10e2b68760be226
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Descripción
Sumario:Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.

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